高级别胶质瘤抗血管生成治疗的标记物的研究
发布时间：2021-03-01 11:03
研究背景高级别胶质瘤是最常见、具有高度增殖和侵袭性的颅内肿瘤,具有难治性、易局部播散和易复发等特点,预后极差,生存期短,如胶质母细胞瘤,中位生存期14.6-16个月,5年生存率仅为3.4%。胶质瘤的治疗需要结合手术切除、化疗、放疗和基于肿瘤的组织学和分子特征的靶向治疗。胶质瘤的分子靶向药物是根据脑胶质瘤发生及生长的分子遗传学信号系统所设计,可以靶向特异靶点,阻断肿瘤的生长,可以明显提高患者无瘤生存期。血管内皮生长因子（vascular endothelial growth factor,VEGF）系统是高级别胶质细胞瘤靶向治疗的一个最有吸引力的靶点,高级别脑胶质瘤肿瘤微环境中特别是低氧、炎症因子以及炎症相关细胞聚集,使得VEGF表达量上调,周围存在高水平VEGF-A,通过旁分泌机制促进内皮细胞的增殖、存活和迁移。这导致了脉管系统的紊乱与血脑屏障损伤,VEGF过表达与血管密度、肿瘤分级和总体预后成正比。贝伐单抗具备高亲和力且特异性地结合VEGF-A,是目前神经系统高级别肿瘤最常用的分子靶向药物,可有效的抑制新生血管生成,对肿瘤的生长起到明显的治疗效果。自2009美国食品和药物管理局批准贝...
【文章来源】：山东大学山东省 211工程院校 985工程院校 教育部直属院校
【文章页数】：80 页
【学位级别】：博士
【部分图文】：
胶质瘤组织的D2-40,VEGF-G,VEGF-D和VEGFR3染色(200X)
图２．?Ｄ２－４０和ＶＥＧＦＲ３在高级别㈧和低级别（Ｂ）的胶质瘤中的表达差异
图３．胶质瘤组织中Ｄ２－４０，?ＶＥＧＦ－Ｃ，ＶＥＧＦ－Ｄ和ＶＥＧＦＲ－３的表达。以下是代表性??的图片：（Ａ）?Ｄ２－４０阳性的胶质瘤ＩＶ?（＋）。?（Ｂ）?ＶＥＧＦ－Ｃ阳性的胶质瘤ＩＶ?（＋＋）。??（Ｃ）?ＶＥＧＦ－Ｄ阳性的胶质瘤ＩＶ?（＋＋）。（Ｄ）?ＶＥＧＦＲ－３阳性的胶质瘤ＩＶ?（＋）。??
【参考文献】：
期刊论文
[1]Association of serum vascular endothelial growth factor-C and lymphatic vessel density with lymph node metastasis and prognosis of patients with gastric cancer[J]. Tian-Bao Wang, Mei-hai Deng, Wan-Shou Qiu, Department of General Surgery, the Third Affiliated Hospital, SUN Yat-Sen University, Guangzhou 510630, Guangdong Province, ChinaWen-Guang Dong, Department of Gastrointestinal Surgery, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, Guangdong Province, China. World Journal of Gastroenterology. 2007(12)
[2]Expression of vascular endothelial growth factor-C and the relationship between lymphangiogenesis and lymphatic metastasis in colorectal cancer[J]. Yi-Tao Jia Wei Liang Department of Oncology,the People’s Hospital of Hebei Province,Shijiazhuang 050051,Hebei Province,China Zhong-Xin Li Yu-Tong He Hui-Chai Yang Department of Surgery,the Forth Hospital of Hebei Medical University,Shijiazhuang 050011,Hebei Province,China Hong-Jun Ma Experimental Centre of Electron Microscopy of Hebei Medical University,Shijiazhuang 050011,Hebei Province,China. World Journal of Gastroenterology. 2004(22)
本文编号：3057389
【文章来源】：山东大学山东省 211工程院校 985工程院校 教育部直属院校
【文章页数】：80 页
【学位级别】：博士
【部分图文】：
胶质瘤组织的D2-40,VEGF-G,VEGF-D和VEGFR3染色(200X)
图２．?Ｄ２－４０和ＶＥＧＦＲ３在高级别㈧和低级别（Ｂ）的胶质瘤中的表达差异
图３．胶质瘤组织中Ｄ２－４０，?ＶＥＧＦ－Ｃ，ＶＥＧＦ－Ｄ和ＶＥＧＦＲ－３的表达。以下是代表性??的图片：（Ａ）?Ｄ２－４０阳性的胶质瘤ＩＶ?（＋）。?（Ｂ）?ＶＥＧＦ－Ｃ阳性的胶质瘤ＩＶ?（＋＋）。??（Ｃ）?ＶＥＧＦ－Ｄ阳性的胶质瘤ＩＶ?（＋＋）。（Ｄ）?ＶＥＧＦＲ－３阳性的胶质瘤ＩＶ?（＋）。??
【参考文献】：
期刊论文
[1]Association of serum vascular endothelial growth factor-C and lymphatic vessel density with lymph node metastasis and prognosis of patients with gastric cancer[J]. Tian-Bao Wang, Mei-hai Deng, Wan-Shou Qiu, Department of General Surgery, the Third Affiliated Hospital, SUN Yat-Sen University, Guangzhou 510630, Guangdong Province, ChinaWen-Guang Dong, Department of Gastrointestinal Surgery, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, Guangdong Province, China. World Journal of Gastroenterology. 2007(12)
[2]Expression of vascular endothelial growth factor-C and the relationship between lymphangiogenesis and lymphatic metastasis in colorectal cancer[J]. Yi-Tao Jia Wei Liang Department of Oncology,the People’s Hospital of Hebei Province,Shijiazhuang 050051,Hebei Province,China Zhong-Xin Li Yu-Tong He Hui-Chai Yang Department of Surgery,the Forth Hospital of Hebei Medical University,Shijiazhuang 050011,Hebei Province,China Hong-Jun Ma Experimental Centre of Electron Microscopy of Hebei Medical University,Shijiazhuang 050011,Hebei Province,China. World Journal of Gastroenterology. 2004(22)
本文编号：3057389
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