3′-Daidzein sulfonate sodium improves mitochondrial function

发布时间：2022-01-14 09:57

　　3′-Daidzein sulfonate sodium is a new synthetic water-soluble compound derived from daidzein（an active ingredient of the kudzu vine root）. It has been shown to have a protective effect on cerebral ischemia/reperfusion injury in rats. We plan to study the mechanism of its protective effect. 3′-Daidzein sulfonate sodium was injected in rats after cerebral ischemia/reperfusion injury. Results showed that 3′-daidzein sulfonate sodium significantly reduced mitochondrial swelling, significantly elevat... 

【文章来源】：Neural Regeneration Research. 2017,12(02)SCICSCD

【文章页数】：7 页

【文章目录】：
Graphical Abstract
Introduction
Materials and Methods
    Experimental animals
    Establishment of rat middle cerebral artery occlusion(MCAO)models
    Drug administration
    Determination of infarct volume
    Neurological deficit scores
    Extraction of rat brain mitochondria
    Mitochondrial swelling assay
    Detection of mitochondrial membrane potential
    Measuring mitochondrial malondialdehyde(MDA)content,superoxide dismutase(SOD),and glutathione peroxidase(GSH-Px)activity
    Evaluation of BBB permeability
    Observation of neurovascular unit ultrastructure by electron microscopy
    Statistical analysis
Results
    Effects of DSS on neurological scores in rats with cerebral I/R injury
    Effects of DSS on cerebral infarct volume in rats with cerebral I/R injury
    Effects of DSS on mitochondrial swelling following cerebral I/R injury in the rat brain
    Effects of DSS on mitochondrial membrane potential in the rat brain after cerebral I/R injury
    Effects of DSS on mitochondrial oxidative stress following cerebral I/R injury
    Effects of DSS on BBB permeability in rats with cerebral ischemia/reperfusion injury
    Effects of DSS on BBB ultrastructure in rats with cerebral ischemia/reperfusion injury
Discussion


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