13-Methyltetradecanoic acid mitigates cerebral ischemia/repe

发布时间：2024-02-03 21:42

　　13-Methyltetradecanoic acid can stabilize cell membrane and have anti-inflammatory,antioxidant and anti-apoptotic effects.Previous studies mainly focused on peripheral nerve injury,but seldom on the central nervous system.We investigated whether these properties of 13-methyltetradecanoic acid have a neuroprotective effect on focal cerebral ischemia/reperfusion injury,and detected the expression of basic fibroblast growth factor and vascular endothelial growth factor.This study established rat mo...

【文章页数】：7 页

【文章目录】：
Introduction
Materials and Methods
    Animals
    Middle cerebral artery occlusion/reperfusion (MCAO/R) modeling
    Administration of drugs
    Measurement of infarct volume and cerebral edema analysis
    Cerebral edema analysis
    Blood-brain barrier (BBB) permeability detection
    Reverse transcription-polymerase chain reaction (RT-PCR)
    Immunohistochemistry of b FGF and VEGF
    Statistical analysis
Results
    Changes in infarct volume and cerebral edema after ischemia/reperfusion injury
    Evans blue content in brain tissue of rats with ischemia/reperfusion injury
    Expression of b FGF and VEGF m RNA in brain tissue of rats with ischemia/reperfusion injury
    Immunoreactivities of b FGF and VEGF in brain tissue of rats with ischemia/reperfusion injury
Discussion



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