基于WHO 2016版分类探讨纹理分析对胶质瘤的鉴别诊断

发布时间：2024-06-15 03:12

　　目的:基于2016版WHO中枢神经系统肿瘤分类,应用常规MRI纹理分析鉴别Ⅱ、Ⅲ、Ⅳ级脑胶质瘤以及其基因突变情况,探讨纹理参数与病理-基因变化的相关性,从而明确纹理分析是否可以常规应用于脑胶质瘤的无创性诊断和治疗计划中。材料和方法:回顾性研究51例脑胶质瘤患者(女27例,男24例):其中15例WHOⅡ型胶质瘤,19例WHOⅢ型胶质瘤,17例WHOⅣ型胶质瘤。术前使用1.5T MRI((Signa HDxt,General Electronic Co,Milwaukee,WI,USA)进行轴位T1WI、T2WI和T1WI增强序列扫描,在ADW4.6工作站生成DICOM格式图像。使用omnikinetics软件(GE Healthcare,CHINA)进行纹理分析(MR texture analysis,MRTA),在T1WI、T2WI、T1WI增强的每层图像上沿肿瘤全域的边缘手动描绘ROI,然后将所有层面的ROI累加为一个3D ROI。本研究分为五组:第一组根据肿瘤的等级(WHO II-III-IV)确定;其他四组根据特定基因(P53,IDH-1,GFAP,EGFR)确定,每组分别对比基...

【文章页数】：61 页

【学位级别】：硕士

【文章目录】：
Abstract
摘要
1 INTRODUCTION
2 MATERIELS AND METHODS
    2.1 Study Population
    2.2 MRI Protocols
    2.3 Image features and analysis
    2.4 Statistical analysis
3 RESULTS
    3.1 Clinical and genetic data
    3.2 MRTA comparison between grades II, III and IV
    3.3 MRTA of gliomas with P53 mutation
    3.4 MRTA of gliomas with IDH-1 mutation
    3.5 MRTA of gliomas with GFAP-mutation
    3.6 MRTA of gliomas with EGFR-mutation
    3.7 Correlation of MRTA parameters with percentage of Ki-67
4.DISCUSSION
5.LIMITATIONS
6.CONCLUSION
REFERENCES
Literature Review
    1 INTRODUCTION
    2 TEXTURE ANALYSIS
    3 CEREBRAL GLIOMAS
        3.1 GENETICS
        3.2 SYMPTOMS
        3.3 SPECIFIC FEATURES
            3.3.1 Low Grade Diffuse Astrocytoma (WHO II) [24,25,26,27]
            3.3.2 Anaplastic Astrocytoma (WHO III) [9,7, ,6,]
            3.3.3 Oligodendroglioma (WHO II)[33,34,35]
            3.3.4 Anaplastic Oligodendroglioma (WHO III) [45,46,35]
            3.3.5 Oligoastrocytoma:
            3.3.6 Glioblastoma (WHO IV) [48,49]
        3.4 TREATMENT
    4 MRI TEXTURE ANALYSIS OF CEREBRAL GLIOMAS
    5 CONCLUSIONS
    REFERENCES
附件
Acknowledges



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