纤维环组织工程的发展及挑战

发布时间：2018-01-13 23:34

本文关键词：纤维环组织工程的发展及挑战　出处：《中国修复重建外科杂志》2015年04期 　论文类型：期刊论文

【摘要】：目的对纤维环组织工程的材料及应用前景进行综述。方法广泛查阅近年来有关纤维环组织工程的相关文献,对种子细胞、生物活性分子及生物材料的研究进展进行综述。结果 MSCs是种子细胞的理想选择;当纤维环细胞和MSCs联合培养时,两者最佳培养比例为2∶1。生物活性分子可分成生长因子、形态因子、酶抑制剂和细胞内调节剂四种类型,它们在促进纤维环细胞外基质分泌、维持椎间盘内环境稳态及代谢平衡方面发挥积极作用。生物材料依据材料来源分为天然材料、人工合成材料和复合材料;纤维环的力学特性是材料设计的重要依据。当前尚无公认的最合适支架材料,支架材料选择仍需进一步研究;新型复合材料的开发是发展趋势。结论纤维环组织工程在纤维环再生修复研究中具有广阔临床应用前景。
[Abstract]:Objective to review the materials and application prospects of fibrous ring tissue engineering. Results MSCs is an ideal choice for seed cells. The optimal culture ratio of fibroring cells and MSCs was 2: 1. The bioactive molecules could be divided into four types: growth factor, morphological factor, enzyme inhibitor and intracellular regulator. They play an active role in promoting the secretion of extracellular matrix and maintaining the homeostasis and metabolic balance in the intervertebral disc. The biomaterials are divided into natural materials, synthetic materials and composite materials according to the source of the materials. The mechanical properties of fiber ring are the important basis of material design. There is no recognized most suitable scaffold material at present, and the choice of scaffold material still needs further study. Conclusion Fiber ring tissue engineering has a broad clinical application prospect in the research of fiber ring regeneration and repair.
【作者单位】：四川大学华西医院骨科;
【分类号】：R318.08
【正文快照】： 椎间盘退变是临床常见病,外科治疗手段包括髓核摘除术、人工椎间盘置换术和减压固定融合术等。手术在多数情况下可缓解症状,但无法逆转退变,术后手术节段或相邻节段椎间盘退变加速,导致髓核再次突出、腰椎节段不稳、腰椎管狭窄等疾病。近年来,通过组织工程技术再生修复椎间盘

【共引文献】