共固化法激光快速成形制备个体化生物陶瓷支架的探讨

发布时间：2018-02-01 16:16

本文关键词： 快速成形骨组织工程个体化陶瓷支架　出处：《哈尔滨医科大学学报》2014年06期 　论文类型：期刊论文

【摘要】：目的研究利用共固化法激光快速成形制备个体化生物陶瓷支架的可行性。方法首先建立立方纵孔生物陶瓷支架三维数字模型,利用激光快速成形技术制备的光硬化树脂负型母板实体,分别用传统聚乙烯醇和光硬化树脂作为结合剂与三磷酸钙粉末混合制备粉浆并填充入负模板,后者烧结前紫外光照射共硬化3 h,随后高温烧结制备陶瓷支架,进行形态学观察和生物亲和性考察。结果传统聚乙烯醇组烧结的支架孔道结构融合且裂隙形成,而共固化法烧结的支架孔道结构精细无融合,无裂缝产生,生物亲和性良好。结论共固化法激光快速成形技术可以作为间接法制备个体化生物陶瓷支架的新技术应用于组织工程中。
[Abstract]:Objective to study the feasibility of fabricating individual bioceramic scaffolds by laser rapid prototyping. Methods the three-dimensional digital model of cubic longitudinal hole bioceramic scaffolds was established. The negative matrix of photohardening resin prepared by laser rapid prototyping was mixed with calcium triphosphate powder and PVA as binder and filled with negative template. The latter was sintered by UV irradiation for 3 h and then sintered at high temperature to prepare ceramic scaffolds. The morphology and biological affinity of the sintered scaffold were observed. Results the pore structure of the traditional polyvinyl alcohol sintered scaffold was fused and the cracks were formed, while the structure of the scaffold sintered by co-solidification method had no fine fusion and no cracks. Conclusion Co-curing laser rapid prototyping can be used in tissue engineering as a new indirect method for the preparation of individual bioceramic scaffolds.
【作者单位】：哈尔滨医科大学附属第二医院骨科;哈尔滨医科大学附属第二医院科研实验中心;东京大学工学部再生医工学研究室;
【基金】：黑龙江省自然科学基金资助项目(LC201020) 黑龙江省卫生厅科研课题(2010-094) 哈尔滨市科技创新人才专项基金(2011RFLYSO31) 黑龙江省教育厅海外学人科研资助项目(1155h014)
【分类号】：R318.08
【正文快照】： 再生医工学研究室,东京113-8656)构建个体化组织工程骨是骨组织工程学中的重要课题,而制备个体化多孔骨支架是其实现的前提。近年来直接从计算机模型产生三维物体的快速成形技术(rapid prototyping,RP)为构建具有精确控制三维结构的个体化骨工程支架提供了希望[1]。利用快速成

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