高分辨率小动物Micro Insert PET系统的模拟研究

发布时间：2018-02-05 22:14

本文关键词： 蒙特卡罗仿真小动物PET Micro Insert系统图像重建　出处：《核技术》2014年11期 　论文类型：期刊论文

【摘要】：在西门子Micro PET小动物成像系统中接入高分辨率的Insert探测器环,组成了Micro Insert PET系统,可以进一步提高小动物PET系统的图像分辨率。本文采用蒙特卡罗模拟软件GATE定义Focus-220小动物PET和Micro Insert两种系统,在同步仿真运算中,给出了三种类型的符合数据,即PET Scanner和PET Scanner之间的符合、PET Scanner和Insert之间的符合、Insert和Insert之间的符合。用滤波反投影算法重建了Na-22单点源模型、多点源模型、LZU模型的PET图像。其中,多点源模型的径向图像分辨率的仿真结果与美国华盛顿大学的Micro Insert实验数据,在忽略正电子射程、非线性效应项以及噪声等的贡献下,两者符合得很好。研究表明,使用Micro Insert系统能够将小动物PET系统的图像分辨率提高到亚毫米水平。
[Abstract]:The high resolution Insert detector ring is connected to Siemens Micro PET small animal imaging system to form Micro Insert PET system. The image resolution of small animal PET system can be further improved. In this paper, we use Monte Carlo simulation software GATE to define Focus-220 small animal PET and Micro. Insert systems. In the synchronous simulation, three types of coincidence data are given, that is, the coincidence between PET Scanner and PET Scanner. The coincidence between PET Scanner and Insert is between insert and Insert. The single point source model of Na-22 is reconstructed by filtering backprojection algorithm. The radial resolution of the multi-point source model and the experimental data of Micro Insert at the University of Washington, USA, are obtained by the simulation of the radial image resolution of the multi-point source model and the PET image of the LZU model. Both agree well with the contribution of positron range, nonlinear effect term and noise. Using the Micro Insert system, the image resolution of the small animal PET system can be improved to sub millimeter level.
【作者单位】：兰州大学核科学与技术学院;
【基金】：国家自然基金项目(No.11305083) 兰州大学国家级大学生创新创业训练计划项目(No.201310730129)资助
【分类号】：R817

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