靶向药物洗脱支架压握过程的力学性能

发布时间：2018-02-10 02:30

本文关键词： 药物洗脱支架压握过程力学性能有限元分析　出处：《医用生物力学》2014年06期 　论文类型：期刊论文

【摘要】：目的研究两种不同结构的药物洗脱支架(drug eluting stent,DES)压握过程的力学性能,以期对DES结构设计提供科学的指导。方法采用Solidworks软件分别建立支架外表面没有刻槽的传统DES(I型支架)以及支架外表面有刻槽的靶向DES(II型支架);通过ABAQUS有限元分析软件,对两种支架压握过程中的径向紧缩反弹比、轴向紧缩反弹比、压握不均匀性、残余应力分布等重要的力学性能指标进行分析。结果同一紧缩外径条件下,两种支架径向紧缩反弹比、轴向紧缩反弹比以及压握不均匀性指数的差值分别在0.07%~0.12%、0.016%~0.033%、0.013%~0.048%之间,II型支架支撑体上存在面积更大的低应力区域。结论相比传统DES支架,靶向DES支架在减少载药量的同时,力学性能并未降低,对心血管狭窄等疾病的治疗具有较好的临床应用前景。
[Abstract]:Objective to study the mechanical properties of two kinds of drug-eluting stents (eluting stentstone des) in the process of pressing. In order to provide scientific guidance for the structural design of DES, Solidworks software was used to establish the traditional DES(I bracket with no grooves on the outer surface of the bracket, and the target DES(II bracket with grooves on the outer surface of the bracket, and the finite element analysis software ABAQUS was used. Some important mechanical performance indexes, such as radial compression rebound ratio, axial compression rebound ratio, uneven grip, residual stress distribution and so on, are analyzed. The difference of radial compression rebound ratio, axial compression rebound ratio and pressure non-uniformity index of two kinds of supports are 0.070.12 and 0.0163.0.033% and 0.048% respectively. Conclusion compared with the traditional DES scaffolds, there are larger low-stress areas on the support body of type II bracket, and the ratio of radial compression rebound ratio and axial compression rebound ratio of the two kinds of supports are 0.070.12 and 0.033 respectively. The mechanical properties of targeted DES stents are not decreased while the drug load is reduced, so it has a good clinical application prospect in the treatment of cardiovascular stenosis and other diseases.
【作者单位】：上海理工大学医疗器械与食品学院教育部微创医疗器械工程研究中心;
【基金】：上海市科委产学研医合作项目(11DZ1921604) 上海市科委医疗器械科技支撑项目(12441903200)
【分类号】：R318.01

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