医用镁及镁合金表面可生物降解有机高分子涂层的应用

发布时间：2018-02-11 00:04

本文关键词： 镁及镁合金有机高分子涂层生物降解性能生物相容性功能化　出处：《表面技术》2017年03期 　论文类型：期刊论文

【摘要】：近年来,镁及镁合金由于其生物可降解性和良好的生物相容性,在医疗器械领域的应用获得了迅速的发展,然而过快的降解速率限制了其在临床上的应用。可生物降解有机高分子涂层是一种降低镁及镁合金降解速率的有效表面改性方法,同时还可赋予镁及镁合金医疗器械多种功能性。首先综述了可降解有机高分子涂层对镁及镁合金耐腐蚀性能和生物相容性的影响。可降解聚合物涂层能阻碍腐蚀性介质与基体的接触,从而延长其降解时间。而涂层对基体的保护提供了碱性较弱的环境,更利于细胞的生长增殖;同时涂层随着基体一起降解,可降低聚合物长期存在生物体内可能引发炎症反应的风险。此外,对聚合物涂层在骨科以及心血管支架领域的应用以及进展进行了综述。一方面,可降解聚合物涂层能显著延长镁及镁合金在生物体内的作用时间;另一方面,涂层可以作为载体材料通过携带具有不同功能的试剂或者药物实现医疗器械的功能化,如促进骨愈合和药物的可控释放。因此,可降解聚合物涂层在镁和镁合金器械领域必将起到无可替代的作用。
[Abstract]:In recent years, magnesium and magnesium alloys have been rapidly developed in the field of medical devices due to their biodegradability and good biocompatibility. However, too fast degradation rate limits its clinical application. Biodegradable organic polymer coating is an effective surface modification method to reduce the degradation rate of magnesium and magnesium alloys. The effects of degradable organic polymer coatings on corrosion resistance and biocompatibility of magnesium and magnesium alloys were reviewed. The contact between the medium and the matrix, Thus, the degradation time is prolonged. The coating provides a less alkaline environment for the substrate, which is more conducive to cell growth and proliferation, and the coating degrades along with the substrate. In addition, the application and progress of polymer coating in orthopedic and cardiovascular stent field are reviewed. Biodegradable polymer coatings can significantly prolong the time of action of magnesium and magnesium alloys in vivo. On the other hand, the coatings can be used as carrier materials to realize the functionalization of medical devices by carrying reagents or drugs with different functions. Therefore, degradable polymer coatings will play an irreplaceable role in the field of magnesium and magnesium alloy instruments.
【作者单位】：上海交通大学;
【基金】：国家自然科学基金项目(51571143,51501115) 上海市科委基金项目(14DZ1940800) 国家科技支撑项目(2012BAI18B01)~~
【分类号】：R318.08;TG174.4

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