组织工程骨支架内部微流体流场研究进展

发布时间：2018-02-16 03:56

  本文关键词： 组织工程支架 流场 微流动 流-固耦合 流体剪应力　出处：《机床与液压》2017年15期 　论文类型：期刊论文

【摘要】：组织工程支架的结构、空间走向、孔隙率是制约组织工程学发展的重要因素,支架内微流体流场直接影响着细胞的吸附、增殖、分化和流-固耦合引起的支架应力应变,且支架内微流体流场各种因素交互作用复杂,作用机制尚未明确,对其内部微管孔中的微流体流动特性的研究尚处于起步阶段。通过对组织工程支架内部流场及流体剪应力和新组织相互影响的研究情况进行阐述,发现在使用数值方法进行模拟仿真的同时,还缺少相应的物理实验验证,而快速成型技术和新材料的发展,对搭建微流体实验平台,探索骨支架及内部微流体流场的优化具有一定的工程意义。
[Abstract]:The structure, spatial direction and porosity of tissue engineering scaffolds are important factors restricting the development of tissue engineering. The microfluid flow field in scaffolds directly affects the adsorption, proliferation, differentiation and stress-strain of scaffolds caused by fluid-solid coupling. The interaction of various factors in the microfluid flow field in the scaffold is complex, and the mechanism of the interaction is not clear. The study on the flow characteristics of microfluid in the inner microtubules is still in its infancy. Through the study of the flow field in the scaffold and the interaction between the fluid shear stress and the new structure, the paper describes the flow field of the scaffold and the interaction between the flow field and the new structure. It is found that the numerical method is used to simulate and simulate, and the corresponding physical experiment verification is lacking. However, with the development of rapid prototyping technology and new materials, the micro-fluid experimental platform is built. It is of engineering significance to explore the optimization of bone scaffold and internal microfluid flow field.
【作者单位】： 燕山大学河北省重型机械流体动力传输与控制重点实验室;唐山工业职业技术学院机械工程系;燕山大学医院;
【基金】：国家自然基金资助项目(51175448;51405424)
【分类号】：R318.08
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本文编号：1514601