髓芯减压联合β-磷酸三钙生物陶瓷治疗早期非创伤性股骨头坏死

发布时间：2018-02-21 16:32

本文关键词： 股骨头坏死减压术外科磷酸钙类组织工程生物材料骨生物材料生物陶瓷 β-三磷酸钙髓芯减压　出处：《中国组织工程研究》2017年06期 　论文类型：期刊论文

【摘要】：背景:国内外关于β-磷酸三钙生物陶瓷基础研究报道比较多,其用于治疗股骨头坏死的报道少见。目的:分析髓芯减压联合β-磷酸三钙生物陶瓷治疗ARCOⅠ/Ⅰ/ⅠA非创伤性股骨头坏死的近期疗效。方法:采用髓芯减压合并β-磷酸三钙生物陶瓷植入治疗ARCOⅠ/Ⅰ/ⅠA非创伤性股骨头坏死患者12例16髋。治疗前后进行Harris评分及影像学观察。以末次随访的Harris评分或影像学显示病情有进展或发生严重并发症的前次Harris评分为最终评分。结果与结论:1所有病例未出现骨折、感染等并发症,均获得随访,平均时间19个月(11-30个月);2治疗前Harris评分为(73.61±3.70)分,治疗后为(84.88±7.11)分,差异有非常显著性意义(P0.001);3疗效:优5例5髋、良5例9髋、中1例1髋、差1例1髋,优良率为88%(14/16);4治疗后1例ⅠC期及1例ⅢA期股骨头坏死出现影像学进展,后者改行全髋置换,余病例影像学均未见明显进展;5结果表明,髓芯减压联合β-磷酸三钙生物陶瓷治疗ARCOⅠ/Ⅰ/ⅠA非创伤性股骨头坏死可获得良好的近期疗效。
[Abstract]:Background: at home and abroad on tricalcium phosphate ceramic Research Foundation reported more, for the treatment of femoral head necrosis reported rare. Objective: to analyze the curative effect of core decompression combined with beta tricalcium phosphate treatment of ARCO 1 / 1 / 1 A non traumatic osteonecrosis of the femoral head. Methods: the spinal cord core decompression combined with beta tricalcium phosphate bioceramic implantation in the treatment of ARCO I / 1 / 1 A non traumatic osteonecrosis of the femoral head in 12 patients with 16 hips. Before and after treatment Harris score and imaging observation. At last follow-up Harris scores or radiographic progression or show serious complications of the previous Harris score the final score. Results and conclusion: all 1 cases showed no fracture, infection and other complications, were followed up, the average time of 19 months (11-30 months); 2 before treatment Harris score was (73.61 + 3.70), after treatment for (84.88 + 7.11), the difference was very Significant (P0.001); 3 curative effect: 5 cases 5 hips, 9 hips in 5 cases were good, 1 cases of 1 hips, 1 hips and poor in 1 cases, the excellent rate was 88%; 4 (14/16) after the treatment of 1 cases of C and 1 cases of stage A necrosis of the femoral head appeared radiographic progression, the latter diverted to total hip replacement, there was no obvious progress in more than 5 cases of imaging; the results show that the core decompression combined with beta tricalcium phosphate treatment of ARCO 1 / 1 / 1 A non traumatic osteonecrosis of the femoral head can obtain good clinical effect.

【作者单位】：南方医科大学珠江医院骨科中心;
【基金】：广东省省级科技计划项目(2014A020212668);课题名称:滑膜成纤维样细胞中HIF-1α-RANKL/OPG通路在假体无菌松动中作用研究~~
【分类号】：R318.08;R681.8

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