电纺纳米纤维可降解输尿管支架肌肉埋植的降解性能及组织相容性

发布时间：2018-02-27 22:15

本文关键词： 电纺丝肌肉埋植降解性能可降解输尿管支架局部组织反应　出处：《吉林大学》2012年硕士论文　论文类型：学位论文

【摘要】：背景：作者前期研究了电纺纳米纤维聚乳酸-羟基乙酸共聚物可降解输尿管支架材料的体外降解性能，发现80/20聚乳酸-羟基乙酸共聚物电纺纳米纤维材料在尿液中的降解时间可以满足临床需要。目的：观察80/20聚乳酸-羟基乙酸共聚物电纺纳米纤维输尿管支架的肌肉埋植降解性能及局部组织反应。方法：采用静电纺丝法制备80/20聚乳酸-羟基乙酸共聚物纳米纤维输尿管支架，观察其在家兔脊柱旁肌肉中的降解情况及并对管周局部组织行病理学检查。结果与结论：成功制备了电纺纳米纤维输尿管支架，，扫描电镜见微观形貌良好。80/20的聚乳酸-羟基乙酸共聚物纳米纤维输尿管支架在体内降解至10周时，支架管降解至初始质量的60%左右，支架出现断裂和崩解。虽降解速度较体外降解稍慢，但其降解性能仍能够满足临床对可降解输尿管支架的需要。管周肌肉组织在植入早期形成轻度的可逆性非细菌性炎症反应。有良好的研究价值。
[Abstract]:Background: the biodegradable ureteral scaffolds of electrospun nano-fiber poly (lactic acid-glycolic acid) copolymer were studied in vitro. It was found that the degradation time of 80/20 polylactic acid-glycolic acid copolymers in urine can meet the clinical needs. Aim: to observe the degradation and local tissue reaction of 80/20 poly (lactic acid-glycolic acid) copolymer electrospun nanofiber ureteral scaffold. Methods: 80/20 poly (lactic acid-glycolic acid) nano-fiber ureteral scaffolds were prepared by electrospinning method. The degradation of the scaffolds in the paraspinal muscles of rabbits and the pathological examination of peritube tissues were observed. Results and conclusion: electrospun nanofiber ureteral stents were successfully prepared. SEM showed that 80 / 20 poly (lactic acid-glycolic acid) copolymer ureteral scaffolds were degraded to 10 weeks in vivo. When the scaffold tube was degraded to about 60% of the initial mass, the scaffold was broken and disintegrated, although the degradation rate was a little slower than that in vitro. However, its degradability can still meet the clinical needs of degradable ureteral stents. The peritube muscle tissue develops mild reversible non-bacterial inflammation at the early stage of implantation, which has good research value.
【学位授予单位】：吉林大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R318.08

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