大鼠嗅球异质性球旁细胞的电生理仿真建模研究

发布时间：2018-03-04 19:18

本文选题：嗅觉神经系统　切入点：球旁细胞　出处：《浙江大学》2012年硕士论文　论文类型：学位论文

【摘要】：研究神经系统最直接的方法就是分析感觉神经系统的工作机制。相比其余感觉神经系统,嗅觉神经系统由于结构简单,已经成为人们认知神经系统、探索脑信息处理机制以及记忆机制的良好的切入点。近年来,嗅球球旁细胞在生物进化过程中的演变机理及其在嗅觉信息编码中所起的作用正逐渐引起了该研究领域的普遍关注。从基于仿真建模分析的神经信息编码研究来看,完善的球旁细胞电生理模型对上述问题的认知有着十分重要的作用。本文首先简介了嗅觉神经系统的解剖结构、主要细胞类型、嗅觉传导通路以及嗅觉神经系统的电生理特性。随后,重点阐述了基于球旁细胞化学、形态、离子通道和动作电位发放等不同分类标准的球旁细胞异质性研究的最新进展。接着,相应地,按照其中钾离子通道的分类标准和动作电位发放的分类标准,分别建立了异质性球旁细胞的电生理模型,分析了这些模型与球旁细胞异质性电生理实验研究之间存在的问题和缺陷。最后,针对上述问题,结合作者现有的工作提出了嗅球球旁细胞电生理、建模以及嗅觉信息编码等研究工作的未来发展方向。本文建立的异质性球旁细胞电生理模型,能够为建立一个更符合生理实际的电生理网络模型打下良好的基础,从而可以帮助人们进一步研究嗅觉信息编码机制。
[Abstract]:The most direct way to study the nervous system is to analyze the working mechanism of the sensory nervous system. Compared with the other sensory nervous systems, the olfactory nervous system has become the cognitive nervous system because of its simple structure. Explore the brain information processing mechanism as well as memory mechanism good breakthrough point. In recent years, The mechanism of olfactory bulb cell evolution in biological evolution and its role in olfactory information coding have gradually attracted the attention of this research field. From the point of view of neural information coding based on simulation modeling analysis, The perfect model of electrophysiology plays an important role in the cognition of the above problems. In this paper, the anatomic structure, main cell types, olfactory conduction pathway and electrophysiological characteristics of olfactory nervous system are introduced. Recent advances in the study of the heterogeneity of paracyclic cells in different classification criteria, such as ion channels and action potential release. Accordingly, according to the classification criteria of potassium channel and action potential release, The electrophysiological models of the heterogenous paracyclic cells were established, and the problems and defects between these models and the experimental studies on the heterogeneity of the periglobular cells were analyzed. Finally, in view of the above problems, Combined with the author's existing work, the future development of the research on the electrophysiology, modeling and olfactory information coding of the olfactory bulb cells is proposed. The electrophysiological model established in this paper can lay a good foundation for the establishment of a more realistic electrophysiological network model, which can help people to further study the encoding mechanism of olfactory information.
【学位授予单位】：浙江大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R318.18

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