人体松质骨矿质密度与弹性模量关系

发布时间：2018-03-05 10:17

本文选题：生物力学　切入点：松质骨　出处：《医用生物力学》2014年05期 　论文类型：期刊论文

【摘要】：目的测量人体多部位松质骨矿质密度、轴向弹性模量,建立矿质密度与轴向弹性模量相关关系的本构方程,为国人有限元材料属性赋值提供依据。方法采取10例成人新鲜尸体作为样本源,选取胫骨近端、大转子、股骨颈、肱骨头和椎体5个部位的松质骨,加工成直径约6 mm、长约30或40 mm的准试样。测量尺寸并计算体积,CT扫描试样骨矿质密度。对松质骨试样进行力学性能测试,分析不同部位松质骨弹性模量。对矿质密度与轴向弹性模量关系进行线性与幂次回归分析。结果测试成功的试样来自5个部位,共169枚,其中胫骨近端52枚,大转子31枚,股骨颈15枚,肱骨头17枚,椎体54枚;5个部位松质骨矿质密度、轴向弹性模量均有所差异,线性相关性均较好(0.850r20.785),3个部位(胫骨近端、大转子、椎体)的幂次相关性较好(0.871r20.825),2个部位(肱骨头、股骨颈)的幂次相关性较弱(0.671r20.643)。结论各个部位骨矿质密度与轴向弹性模量的线性和幂次回归的相关性均较高,且同部位两种回归的r2值之间无明显差异;可应用于体外检测患者的骨骼质量,准确分辨骨质变化的部位,配合有限元建模能够预测骨折的风险。
[Abstract]:Objective to measure the mineral density and axial elastic modulus of cancellous bone in human body, and to establish the constitutive equation of the relationship between mineral density and axial modulus of elasticity. Methods Ten fresh adult cadavers were used as samples to select cancellous bone in proximal tibia, trochanter, neck of femur, head of humerus and vertebral body. Processed into quasi-specimens of about 6 mm in diameter and about 30 or 40 mm in length. Measurements of dimensions and calculation of bone mineral density of CT scanning specimens. Mechanical properties of cancellous bone specimens, The relationship between mineral density and axial elastic modulus was analyzed by linear and power regression analysis. Results 169 specimens were obtained from 5 parts, including 52 proximal tibia and 31 large trochanter. There were 15 neck of femur, 17 heads of humerus, 54 vertebrae, 5 parts of cancellous bone mineral density and axial modulus of elasticity, the linear correlation was better than 0.850r20.785, 3 parts (proximal tibia, great trochanter), The power correlation of vertebral body is better than that of the other two parts (head of humerus and neck of femur). Conclusion the correlation between bone mineral density and axial modulus of elasticity is higher than that in other two parts (head of humerus, neck of femur), conclusion the correlation between the density of bone mineral and the regression of axial modulus of elasticity is higher in two parts (head of humerus and neck of femur). There is no significant difference between the two regression values of R2 in the same site, which can be used to detect the bone mass of patients in vitro, to distinguish the site of bone change accurately, and to predict the risk of fracture in combination with finite element modeling.
【作者单位】：上海交通大学附属第一人民医院骨科;上海交通大学机械与动力工程学院;
【基金】：国家重点基础研究发展计划(973)子课题(2011CB711005) 国家自然科学基金资助项目(81071234,81272002)
【分类号】：R318

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