超声实时剪切波弹性成像评价脂肪肝的价值

发布时间：2018-03-07 07:46

本文选题：脂肪肝　切入点：实时剪切波弹性成像　出处：《放射学实践》2017年05期 　论文类型：期刊论文

【摘要】：目的:应用超声实时剪切波弹性成像(SWE)技术测量人体脂肪肝硬度的变化,分析脂肪肝硬度(kPa_(Mean))与MR mDixon测得的脂肪含量的相关性,探讨脂肪肝硬度的诊断阈值及SWE技术对脂肪肝的诊断价值。方法:对26例志愿者行传统二维超声、SWE及MR mDixon序列检查。超声检查由两位医师分别进行操作和数据测量,并分析两位医师间的一致性;通过计算Pearson相关系数r1、r2分析两位医师内的可重复性。对SWE测得的硬度值、速度值及MR mDixon测得的脂肪含量分别与传统超声在脂肪肝检出及分度上进行一致性分析,绘制散点图,并得到kPa_(Mean)诊断阈值;对SWE和MR mDixon的测量结果进行相关性分析,计算Pearson相关系数。结果:检验两位医师间的一致性的BlandAltman散点图显示26例中有24个数据位于95㳠一致性界限内;检验两位医师内的可重复性的Pearson相关系数r1=0.917、r2=0.921(P值均0.05);分别计算kPa_(Mean)界值=4、5、6时的Kappa值,当杨氏模量诊断阈值kPa_(Mean)为5kPa时,Kappa值为0.8190.75(P0.05);SWE测得的硬度值(kPa_(Mean))、速度值与MR脂肪含量的Pearson相关系数分别为0.877、0.867,差异均有统计学意义(P值均0.05)。结论:SWE成像技术诊断脂肪肝具有较好的稳定性,可为临床提供脂肪肝患者肝脏硬度方面的信息,与MR mDixon序列检测的肝脏脂肪含量有很高的相关性。
[Abstract]:Objective: to measure the changes of fatty liver hardness by ultrasonic real time shear wave elastic imaging (SWE) technique, and to analyze the correlation between the hardness of fatty liver and the fat content measured by Mr mDixon. To explore the diagnostic threshold of fatty liver hardness and the diagnostic value of SWE technique in fatty liver. Methods: 26 volunteers were examined by conventional two dimensional ultrasound and Mr mDixon sequence. The consistency between the two physicians was analyzed, and the repeatability of the two physicians was analyzed by calculating the Pearson correlation coefficient r 1 and r 2. For the hardness values measured by SWE, The velocity and fat content measured by Mr mDixon were consistent with those of conventional ultrasound in detecting and grading fatty liver, the scattered plot was drawn, and the KPA mean threshold was obtained, and the correlation between the results of SWE and Mr mDixon was analyzed. The Pearson correlation coefficient was calculated. Results: the BlandAltman scatter plot, which examined the consistency between the two physicians, showed that 24 of the 26 cases were located at 95? Within the consistency limit, the reproducible Pearson correlation coefficient r10.917r20.921 P was tested between the two physicians, and the Kappa values of KPA mean and 6:00 were calculated respectively. When the diagnostic threshold value of Young's modulus is 5 KPA, the Kappa value is 0.8190.75 and the Pearson correlation coefficient between velocity and Mr fat content is 0.887 卤0.867, respectively. Conclusion the diagnostic value of w SWE has good stability in the diagnosis of fatty liver, and the correlation coefficient between velocity and Mr fat content is 0.867, P = 0.050.Conclusion\% SWE imaging has good stability in the diagnosis of fatty liver, and the correlation coefficient between velocity value and Mr fat content is 0. 877 卤0. 867, respectively (P = 0. 05, P = 0. 05, P = 0. 05, P = 0. 05, P = 0. 05). It can provide clinical information on liver hardness of fatty liver patients, and has a high correlation with liver fat content detected by Mr mDixon sequence.
【作者单位】：北京积水潭医院超声诊断科;北京积水潭医院放射科;
【基金】：北京市卫生科技成果与适宜技术推广项目资助(NO.TG-2015-07)
【分类号】：R445;R575.5

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