利用等离子体技术调控丝素纤维表面性能诱导其仿生矿化的研究

发布时间：2018-03-07 23:06

本文选题：空气等离子体　切入点：丝素纤维　出处：《蚕业科学》2017年01期 　论文类型：期刊论文

【摘要】：以蚕丝纤维为生物模板的仿生矿化,为骨组织工程和生物材料领域关注热点之一。利用空气等离子体处理改变丝素纤维材料表面理化性能,调控羟基磷灰石纳米棒在材料表面的沉积形貌,制备出仿天然骨组织的丝素纤维/纳米羟基磷灰石(SFF/n HAp)复合材料,并通过傅里叶变换红外光谱(FTIR)、X射线衍射(XRD)、扫描电子显微镜(SEM)及透射电子显微镜(TEM)等对SFF/n HAp复合材料的结构、形貌等理化性质进行分析表征。结果显示,虽然未处理丝素纤维及经空气等离子体处理的丝素纤维均能调控羟基磷灰石在其表面沉积,但后者由于表面产生颗粒结构,粗糙度变大,并且引入的含氧官能团使亲疏水性及结晶度发生了变化,导致沉积其上的羟基磷灰石形貌有所差异,尤其是等离子体处理时间对其影响显著:等离子体处理5 min,羟基磷灰石呈现的棒状结构已不再明显;等离子体处理20 min,羟基磷灰石聚集成簇,且其结晶度最高,结晶型与天然骨组织中n HAp的结晶型类似。用经过空气等离子体处理的丝素纤维制备的丝素纤维/羟基磷灰石复合材料有望用于骨组织修复。
[Abstract]:Biomimetic mineralization of silk fiber as a biological template is one of the hot topics in bone tissue engineering and biomaterials. The surface physicochemical properties of silk fibroin fiber are changed by air plasma treatment. In order to control the deposition morphology of hydroxyapatite nanorods on the surface of the material, silk fibroin fiber / nano-hydroxyapatite fiber / nano-hydroxyapatite fiber / SFF / n HAp-based composite were prepared. The structure, morphology and physical and chemical properties of SFF/n HAp composites were characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscope (TEM). Although both untreated and air-treated fibroin fibers can regulate the deposition of hydroxyapatite on its surface, the roughness of the latter increases due to the formation of particles on the surface. The hydrophobicity and crystallinity of hydrophobicity and crystallinity were changed by introducing oxygen functional groups, which resulted in different morphology of hydroxyapatite deposited on it. The effect of plasma treatment time on the structure of hydroxyapatite was not obvious after 5 mins treatment, and hydroxyapatite clustered into clusters at 20 min after plasma treatment, and the crystallinity of hydroxyapatite was the highest. The crystallite type is similar to that of n HAp in natural bone tissue. The fibroin fiber / hydroxyapatite composite prepared by air plasma treatment is expected to be used for bone tissue repair.
【作者单位】：浙江大学动物科学学院应用生物资源研究所;
【基金】：现代农业产业技术体系建设专项(No.CARS-22) 浙江省自然科学基金重点项目(No.LZ17C170002) 国家高技术研究发展计划“863”项目(No.2013AA102507)
【分类号】：R318.08

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