魔芋葡甘聚糖超多孔杂化水凝胶的制备与表征

发布时间：2018-03-16 22:37

本文选题：魔芋葡甘聚糖　切入点：超多孔杂化水凝胶　出处：《中国实验方剂学杂志》2014年16期 　论文类型：期刊论文

【摘要】：目的:合成并表征魔芋葡甘聚糖超多孔杂化水凝胶(KGM-SPHH)。方法:采用泡沫聚合法制备KGM-SPHH,以溶胀比为评价指标,采用单因素试验考察丙烯酰胺(AM),丙烯酸(AA),N,N',-亚甲基双丙烯酰胺(Bis),普朗尼克F127(PF127),魔芋葡甘聚糖(KGM),过硫酸胺(APS),N,N,N',N',-四甲基乙二胺(TEMED)及NaHCO3用量对合成工艺的影响。利用扫描电子显微镜观察KGM-SPHH的微观形态,FTIR鉴定其化学结构。结果:优选的合成工艺为50%AM溶液2 mL,50%AA溶液0.3 mL,2.5%Bis溶液2 mL,10%PF127溶液0.3 mL,20%APS溶液0.2 mL,KGM 0.1 g,20%TEMED溶液0.2 mL,NaHCO30.2 g。KGM-SPHH呈均相体系,能迅速吸收大量水分并达溶胀平衡,内部含大量孔隙并相互连接呈网络状,含有AAco-AM和交联的KGM。结论:泡沫聚合法可制得多孔状、溶胀迅速的均相KGM-SPHH。
[Abstract]:Objective: to synthesize and characterize konjac glucomannan superporous hybrid hydrogel KGM-SPHHH.Methods: KGM-SPHHH was prepared by foam polymerization, and the swelling ratio was used as the evaluation index. Single factor test was used to investigate the effects of the contents of acrylamide amines, acrylic acid (ANAA) and methylene bisacrylamide, Plannick F127 (PF127), konjac glucomannan (KGMN), amines persulfate (APS) and tetramethyl ethylenediamine (TEMED) and the amount of NaHCO3 on the synthesis process. The microscopic morphology of KGM-SPHH was observed by microscope and its chemical structure was identified by FTIR. Results: the optimum synthetic process was as follows: 50 am solution 2 mL ~ (50) solution 0. 3 mLL ~ (2.5) Bis solution 2 mL ~ (10) Bis solution 0. 3 mL ~ (10) APS solution 0. 2 mL KGM 0. 1 g ~ (20) TEMED solution, 0. 2 mL NaHCO _ (3) 0.2 g 路KGM-SPHH, and 0. 2 mL 路KGM-SPHH, respectively. It can rapidly absorb a large amount of water and achieve swelling equilibrium, with a large number of pores in the interior and connected to each other as a network. Conclusion: porous and rapidly swelling homogeneous KGM-SPHHH can be prepared by foam polymerization.
【作者单位】：宁夏医科大学总医院;宁夏医科大学药学院;宁夏回药现代化工程技术研究中心;回医药现代化省部共建教育部重点实验室;
【基金】：国家自然科学基金项目(30902010)
【分类号】：R318.08

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