骨科金属植入物表面载药抗菌涂层的研究进展

发布时间：2018-03-18 23:00

本文选题：骨科　切入点：金属植入物　出处：《中国修复重建外科杂志》2017年11期 　论文类型：期刊论文

【摘要】：目的总结近年来骨科金属植入物表面载药抗菌涂层的研究进展。方法检索查阅近年来国内外关于骨科金属植入物表面载药抗菌涂层的相关研究报道,对研究现状、分类及发展趋势进行总结。结果骨科金属植入物表面载药抗菌涂层在药物释放方式上可分为被动释放型和主动释放型。被动释放型载药涂层在植入体内后,无论植入物周围有无细菌都会持续被动地释放药物;而主动释放型载药涂层在植入物周围无感染时不释放或少量释放所搭载的药物,仅当其周围出现感染时,主动释放搭载药物,实现智能抗菌。结论药物的持续稳定释放是各种抗菌涂层需解决的关键问题,能够对细菌响应性释放载药的智能型抗菌涂层是今后载药抗菌涂层的发展方向。
[Abstract]:Objective to summarize the research progress in recent years in Department of orthopedics metal implant drug loading on antimicrobial coating. Methods searching in recent years at home and abroad about the related research of Department of orthopedics metal implant surfaces of drug loaded antibacterial coatings, the research status, classification and development trend were summarized. The Department of orthopedics metal implant drug loading on the drug release pattern in antimicrobial coating it can be divided into passive and active release release. The drug loaded coating on the passive release after implantation, the implants were not around whether bacteria will continue to release the passive and active drug; drug release coating in peri implant infection does not release or a small amount of drug release with the only. When around the infection, active release of drug loaded, to achieve sustained and stable conclusion. Intelligent antibacterial drug release is a key problem to solve all kinds of antibacterial coating, to bacterial ring The intelligent antibacterial coating that should release the drug is the development direction of the antiseptic coating in the future.

【作者单位】：吉林大学第一医院骨关节外科;
【基金】：吉林省科技厅项目(20160101131JC) 吉林省卫生与计划生育委员会科研计划(2015Z031)~~
【分类号】：R318.08;R687

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