一种可测量血管应变的光学相干成像系统

发布时间：2018-03-20 04:40

本文选题：血管　切入点：应变　出处：《生物医学工程学杂志》2017年05期 　论文类型：期刊论文

【摘要】：本研究旨在搭建一套可测量血管应变的光学相干层析成像(OCT)系统。首先,利用搭建的OCT系统测量猪冠状动脉结构,并与血管组织切片对比,以确定系统的可靠性;然后,在灌流系统中,对猪冠状动脉施加不同压力,测量不同压力下血管的OCT图像,并使用互相关算法计算血管应变。结果表明,血管的OCT图像呈明暗分层,可以清晰地观察到血管的中膜和内膜,与血管组织切片结果一致。计算得到了不同压力下中膜和内膜的位移和应变,发现中膜应变大于内膜应变。该OCT系统不仅可以测量血管组织形态,还可以测量血管微观尺度的应变。
[Abstract]:The purpose of this study is to set up an optical coherence tomography (Oct) system for measuring vascular strain. Firstly, the structure of porcine coronary artery is measured by using the constructed OCT system and compared with vascular tissue sections to determine the reliability of the system. In the perfusion system, different pressures were applied to the porcine coronary artery to measure the OCT images of blood vessels under different pressures, and the cross correlation algorithm was used to calculate the vascular strain. The results showed that the OCT images of blood vessels were light and dark stratified. The media and intima of blood vessels can be clearly observed, which is consistent with the results of vascular tissue sections. The displacement and strain of the media and intima under different pressures are calculated. It is found that the medium membrane strain is greater than the intimal strain, and the OCT system can not only measure the morphology of blood vessels, but also measure the strain of blood vessels on microscopic scale.
【作者单位】：北京航空航天大学生物与医学工程学院生物力学与力生物学教育部重点实验室;
【基金】：国家自然科学基金资助项目(31570947,11332003,11572028,61533016,11421202,61190123) 北京市优秀博士论文基金(20131000601)
【分类号】：R318;TP391.41

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