血管支架用可降解金属研究进展

发布时间：2018-03-24 13:27

本文选题：可降解金属支架　切入点：镁合金　出处：《金属学报》2017年10期

【摘要】：在过去的20年间,随着对可降解金属研究的不断深入,从合金成分设计到熔炼制造加工,从毛细管到支架激光加工和药物涂覆等相关技术不断成熟。可降解金属支架也从一个概念发展为实际产品,并形成3个材料体系分支:可降解镁合金支架已经开展了大量的动物实验和临床实验,结果显示其良好的表现和临床安全性,Biotronik公司生产的可降解镁合金产品Magmaris在2016年获得CE认证;可降解铁合金支架目前处在动物实验阶段,注氮铁合金支架具有优异的力学性能,动物实验结果显示注氮铁支架具有良好的生物相容性;可降解锌合金支架近几年才得到人们的关注,目前的体内动物实验研究结果显示,纯Zn丝在小鼠体内具有良好的降解性能和生物相容性,暂未见体内支架研究报道。本文在综合评述可降解金属支架材料的研究现状基础上,展望了可降解金属支架在性能优化、药物洗脱和智能化方面的未来发展趋势。
[Abstract]:Over the past 20 years, with the deepening of research on degradable metals, from alloy composition design to smelting manufacturing, Technologies related to laser processing and drug coating from capillary tubes to stents have matured. Degradable metal stents have also evolved from a concept to a practical product. And formed three branches of material system: biodegradable magnesium alloy scaffold has carried out a large number of animal and clinical experiments, The results showed that Magmaris, a biodegradable magnesium alloy produced by Biotronik, was CE certified in 2016. The biodegradable ferroalloy scaffold is currently in the animal experimental stage, and the nitrogen-implanted ferroalloy scaffold has excellent mechanical properties. Animal experiments showed that the nitrogen-implanted iron scaffolds had good biocompatibility, and that biodegradable zinc alloy scaffolds had attracted more and more attention in recent years. Pure Zn wire has good biodegradability and biocompatibility in mice, but there is no in vivo stent research report. On the basis of comprehensive review of the research status of degradable metal scaffolds, the performance optimization of degradable metal scaffolds is prospected. Future trends in drug elution and intelligence.
【作者单位】：北京大学工学院材料科学与工程系;
【基金】：国家重点研发计划项目No.2016YFC1102402 国家自然科学基金重点项目No.51431002~~
【分类号】：R318.08;TG14

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