3D生物打印组织器官及其在口腔医学中的研究与进展

发布时间：2018-04-01 01:05

本文选题：人工器官　切入点：口腔医学　出处：《中国组织工程研究》2017年22期

【摘要】：背景:3D生物打印已被用于研究打印多种组织,包括皮肤、血管、肝脏、软骨、心脏、耳、脂肪等。目的:综述3D生物打印在不同组织器官中的应用及其在口腔医学中的研究进展。方法:应用计算机检索Pub Med数据库、中国知网数据库2006至2016年发表的有关3D生物打印在组织器官及口腔医学中的应用的研究,检索词为"3D bioprinting,3D printing,organs,tissues,tissue engineering,stomatology,oral,cranio-maxillofacial;3D生物打印,器官,组织,组织工程,口腔医学,口腔颅颌面"。结果与结论:目前,已有相当数量的研究利用增材制造原理打印不同组织器官的3D生物支架,但直接的细胞生物打印技术尚处于早期阶段,尽管3D生物打印已被用于研究打印多种组织包括皮肤、血管、肝脏、软骨、心脏等,但还未有成功的具有相关活性功能的3D生物细胞打印组织进入临床应用,并且在口腔医学中,绝大部分研究仍停留于打印生物支架阶段。由于人类机体结构及各组织器官功能表达的复杂性,未来可能仍需要很长一段时间对打印细胞的来源、生物支架材料、细胞外基质类型及3者之间如何更好的相互作用等方面进行不断探索。
[Abstract]:Background: 3D biprint has been used to study the printing of various tissues, including skin, blood vessels, liver, cartilage, heart, ear, fat and so on.Objective: to review the application of 3D biography in different tissues and organs and its research progress in stomatology.Methods: Pub Med database was searched by computer and published from 2006 to 2016 on the application of 3D biometric printing in tissue, organs and stomatology. The key words were "3D biophoric printing or tissue engineering tissue tissue engineering", "organ, tissue, tissue, tissue, tissue, tissue, tissue, tissue, tissue, tissue, tissue, tissue".Tissue Engineering, Stomatology, Oral craniomaxillofacial.Results & conclusion: at present, a considerable number of studies have been done to print 3D scaffolds of different tissues and organs using the principle of material augmentation, but the direct cell bioprinting technology is still in its early stage.Although 3D bioprinting has been used to print various tissues including skin, blood vessels, liver, cartilage, heart, etc., it has not been successfully used in clinical applications.And in Stomatology, most of the research is still at the stage of printing biological scaffolds.Due to the complexity of the structure of the human body and the functional expression of various tissues and organs, it may take a long time in the future to print the source of the cells, the biological scaffold material,The types of extracellular matrix and how to better interact with each other have been explored.
【作者单位】：上海交通大学医学院附属第九人民医院口腔颅颌面科上海市口腔医学重点实验室;
【基金】：国家自然科学基金(81271122,81570947) 上海高校高峰高原学科建设项目上海高校创新团队计划~~
【分类号】：R783.1

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