纳米材料-蛋白质界面相互作用的分子机制

发布时间：2018-04-02 19:14

本文选题：纳米材料　切入点：蛋白质　出处：《物理化学学报》2017年01期

【摘要】：纳米材料由于其优异的性能在化工、电子、机械、环境、能源、航天等各个领域已经得到了广泛的应用,并且在生物医学方面的应用越来越受到重视。纳米材料-蛋白质界面相互作用是纳米生物医学领域重要的科学问题,对于纳米材料的生物医学应用以及生物安全性评价至关重要。蛋白质分子与纳米材料在界面的相互作用,一方面可以诱导蛋白质的构象、组装结构甚至功能的改变,另一方面可以引起纳米材料的表面亲疏水性、电荷性质等表面物理化学性质的改变。基于蛋白质与纳米材料相互作用检测技术及结果,本文从分子水平阐述了纳米材料与蛋白质分子在界面之间的相互作用机理及相应的结构与性质的变化,从而可以深化对两者之间复杂的相互作用机制的理解,对于推进纳米材料在生物医学的应用及健康、安全、持续发展具有重要意义。
[Abstract]:Nanomaterials have been widely used in chemical, electronic, mechanical, environmental, energy, aerospace and other fields because of their excellent properties, and more and more attention has been paid to biomedical applications.The interaction between nanomaterials and proteins is an important scientific issue in the field of nano-biomedicine, which is very important for biomedical application and biosafety evaluation of nanomaterials.The interaction between protein molecules and nanomaterials at the interface can, on the one hand, induce the conformation, assembly structure and even functional changes of proteins; on the other hand, it can induce the surface hydrophobicity of nanomaterials.The change of surface physicochemical properties such as charge properties.Based on the technology and results of the interaction between protein and nanomaterials, the mechanism of interaction between nanomaterials and protein molecules at the interface and the corresponding changes in structure and properties are described from the molecular level.Thus, it can deepen the understanding of the complex interaction mechanism between the two, and it is of great significance to promote the application and health, safety and sustainable development of nanomaterials in biomedicine.
【作者单位】：国家纳米科学中心中国科学院纳米生物效应与安全性重点实验室中国科学院纳米标准与检测重点实验室中国科学院纳米科学卓越创新中心;
【基金】：国家自然科学基金(21273051)资助项目~~
【分类号】：TB383.1;R318

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