基于无线能量传输技术的植入式动物生理参数遥测系统研究

发布时间：2018-04-04 16:20

本文选题：无线能量传输　切入点：植入式　出处：《上海交通大学》2012年硕士论文

【摘要】：植入式遥测是生物医学测量技术发展最快的分支之一,用来长期实时跟踪处于无拘束状态下的生物体的生理或生化参数的变化,这对生物体本身的研究,对采用药物和人工器官及辅助装置的疗效评估都有十分重要的意义。此外,由于测量装置植入体内后,可保证植入装置处在接近恒温和少干扰的良好环境中,使测量准确性大幅度提高。本论文依托上海市赞德医疗器械有限公司横向课题项目“动物生理参数检测系统研究”在国家自然科学基金(NO.30800235)资助下,对植入式动物生理参数监测系统进行了深入研究。论文提出了基于无线能量传输技术的植入式动物生理参数遥测系统的设计方案,系统由无线能量传输设备、植入式微型电子胶囊、体外数据记录仪和数据处理软件组成,无线能量传输设备能够为植入式微型电子胶囊供能,从而避免了频繁更换电池给动物带来的痛苦;植入式微型电子胶囊能够检测到动物的心电、血压和体温三项生理参数信号,通过无线方式将测得的数据发射至体外;体外数据记录仪无线接收、存储和显示数据;上位机数据处理软件读取、处理记录仪存储的数据,并绘制生理参数波形。本文从总体上给出了体内装置和体外装置的结构,着重介绍该系统设计的关键技术。无线能量传输技术体外装置采用矩形螺线管发射线圈为电子胶囊进行供能,电子胶囊内部通过三维线圈接收能量,为电子胶囊正常工作提供能量;植入式微型电子胶囊集成了信号采集、滤波、放大、AD转换功能,通过射频芯片将数据无线发射至体外;体外数据记录仪集成了无线数据接收、存储和液晶显示功能;数据处理软件采用MATLAB进行编写,集成了数据读取功能和绘图功能,为用户提供了图形用户界面。论文通过模拟实验和动物实验验证了系统的性能,模拟实验分别采用直流电压和无线能量传输设备为胶囊供电,直流供电模拟实验表明胶囊能够精确地检测到动物生理参数,无线供能模拟实验表明无线传输的能量能够满足胶囊的正常工作,体外数据记录仪能接收到胶囊发射的数据,但心电信号线必须经过屏蔽才能测得模拟心电信号;动物实验中采用新西兰兔作为实验动物,测得了有效的血压和体温,而心电信号被电磁场淹没。为长期连续监测动物生理参数,本文设计并实现了一种基于无线能量传输技术的植入式遥测系统,植入式微型电子胶囊尺寸仅为Φ13×30mm,重6.38g,功耗约150mW,选用新西兰兔进行活体实验,测得体温范围为37.2-37.3°C,基线噪声为0.1°C,血压范围为74-83mmHg,基线噪声为3mmHg。最后,本文总结了该系统功能上的创新,并提出了系统今后的发展方向,供以后的科研工作参考。
[Abstract]:Implantable telemetry is one of the fastest-growing branches of biomedical measurement technology, which is used to track the changes of physiological or biochemical parameters of organisms in an unconstrained state for a long time in real time.It is of great significance to evaluate the efficacy of drugs, artificial organs and assistive devices.In addition, the accuracy of measurement can be greatly improved because the measuring device is in a good environment of close to constant temperature and less interference after it is implanted into the body.Based on the horizontal project of Shanghai Zander Medical device Co., Ltd., "Research on Animal physiological Parameter Detection system", the implanted animal physiological parameter monitoring system was deeply studied with the aid of National Natural Science Foundation of China (no. 30800235).This paper presents a design scheme of implantable animal physiological parameter telemetry system based on wireless energy transmission technology. The system consists of wireless energy transmission equipment, implanted microelectronic capsule, in vitro data recorder and data processing software.Wireless energy transmission devices can provide energy for implanted microelectronic capsules, thereby avoiding the pain caused by frequent battery changes. Implanted microelectronic capsules can detect three physiological parameters, including ECG, blood pressure and body temperature.The measured data is transmitted to the external body by wireless mode; the external data recorder receives, stores and displays data wirelessly; the upper computer data processing software reads, processes the data stored by the recorder, and draws the physiological parameter waveform.In this paper, the structure of the device in vivo and in vitro is given, and the key technology of the system design is emphatically introduced.In vitro, the rectangular solenoid transmitting coil is used to supply energy for the electronic capsule, which receives the energy through the three-dimensional coil in order to provide the energy for the normal operation of the electronic capsule.The implantable microelectronic capsule integrates the functions of signal acquisition, filtering, amplifying AD conversion, and radio-frequency chip to transmit the data wirelessly to the outside body, and the external data recorder integrates the functions of wireless data receiving, storage and LCD display.The data processing software is written by MATLAB, which integrates the function of data reading and drawing, and provides the user with graphical user interface.The performance of the system is verified by simulation experiments and animal experiments. DC voltage and wireless energy transmission equipment are used to power the capsules respectively. The DC power supply simulation experiments show that the capsules can accurately detect the physiological parameters of animals.The simulation experiment of wireless energy supply shows that the wireless transmission energy can meet the normal operation of the capsule, and the data from the capsule can be received by the in vitro data recorder, but the ECG signal line must be shielded in order to get the simulated ECG signal.In animal experiments, New Zealand rabbits were used as experimental animals to measure effective blood pressure and body temperature, and electrocardiogram (ECG) was submerged by electromagnetic field.In order to continuously monitor animal physiological parameters for a long time, an implantable telemetering system based on wireless energy transmission technology was designed and implemented. The size of implanted microelectronic capsule was only 桅 13 脳 30 mm, the weight was 6.38 g, and the power consumption was about 150 MW.The temperature range was 37.2-37.3 掳C, the baseline noise was 0.1 掳C, the blood pressure range was 74-83 mmHg, and the baseline noise was 3mmHg.Finally, this paper summarizes the innovation of the system function, and puts forward the future development direction of the system for future scientific research work.
【学位授予单位】：上海交通大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R197.39

【引证文献】