生物型柠檬酸钙骨水泥的研制及抗压强度和生物相容性评价

发布时间：2018-04-08 21:57

本文选题：柠檬酸钙　切入点：α-磷酸三钙　出处：《西安交通大学学报(医学版)》2017年05期

【摘要】：目的选择新鲜牡蛎壳为原料,制备生物型柠檬酸钙骨水泥,探讨其抗压强度和生物相容性,为临床上应用该材料提供初步的实验基础。方法利用天然牡蛎壳,制备生物型柠檬酸钙骨水泥,检测该材料的抗压强度,扫描电镜观察其表面形态,测定其在模拟体液中的钙离子释放曲线和pH值变化,并通过细胞毒性试验检测其生物相容性。结果选择0.33mL/g液固比所生成的柠檬酸钙骨水泥抗压强度最大,此时材料的晶体结构均一有序。pH值测定提示柠檬酸钙骨水泥降解吸收过程中并不明显改变体液的pH值,随着材料的逐渐降解,溶液中Ca2+浓度逐渐增大。细胞毒性实验表明该材料生物相容性良好,无明显细胞毒性。结论生物型柠檬酸钙骨水泥材料抗压强度大,生物相容性良好,可形成局部弱碱性、高钙微环境。
[Abstract]:Objective to study the compressive strength and biocompatibility of biotype calcium citrate cement by using fresh oyster shell as raw material, and to provide a preliminary experimental basis for its clinical application.Methods Biotype calcium citrate cement was prepared from natural oyster shell. The compressive strength of the cement was measured. The surface morphology of the cement was observed by scanning electron microscope. The calcium release curve and pH value in simulated body fluid were measured.The biocompatibility was tested by cytotoxicity test.Results the compressive strength of calcium citrate cement produced by 0.33mL/g liquid-solid ratio was the highest, and the determination of crystal structure homogenization and order pH value indicated that the pH value of body fluid was not changed during the degradation and absorption of calcium citrate cement.With the degradation of the material, the concentration of Ca2 in the solution increases gradually.The cytotoxicity test showed that the material had good biocompatibility and no obvious cytotoxicity.Conclusion the biotic calcium citrate cement has high compressive strength and good biocompatibility, and can form a local weak alkaline and high calcium microenvironment.
【作者单位】：西安交通大学第一附属医院骨科;西安交通大学医学部基础医学院生理学与病理生理学系;
【基金】：中央高校基本科研业务费专项资金资助项目(No.XJJ2015024) 西安交通大学第一附属医院院基金资助项目(No.2013YK19)~~
【分类号】：R318.08;R68

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