可降解材料聚丁二酸丁二醇酯的生物医学性能研究

发布时间：2018-04-09 17:23

本文选题：聚丁二酸丁二醇酯　切入点：生物安全性　出处：《北京协和医学院》2012年硕士论文

【摘要】：聚丁二酸丁二醇酯(poly(butylene succinate), PBS)是近年开发成功的可完全降解的脂肪族聚酯材料的一种,其降解产物琥珀酸为人体三羧酸循环的中间产物,这成为其作为医用材料运用于人体的理论出发点。目前PBS作为环境友好型可降解材料,具有降解确实,材料机械性能优异、易于加工等优点。而作为医用生物材料,PBS不仅需要满足严格的生物安全性要求,还需要充分了解PBS在体内外环境下的降解动力学。本项研究延续课题组既往研究,通过对一步法合成的PBS进行提纯处理得到了高纯度的PBS,在生物安全性方面研究了材料的刺激和迟发超敏反应性及初步血液相容性,在降解方面研究了材料在模拟体内环境下的降解行为,与聚乳酸(polylactic acid, PLA)增强共混材料的降解行为,得到如下结论： 1.PBS的提纯处理后未对材料的性能造成影响,而且显著改善了PBS的各项性能； 2.PBS不刺激机体,无抗原性,接触血液不溶血,血小板粘附性接近医用级PLA材料； 3.PBS在模拟体内环境下降解机理为大块降解,降解速率经历由快至慢的转变,转变原因为自催化效应,转变条件为数均分子量(Mn)降低为4×104,降解始于无定形区,后为结晶区。 4.PBS与PLA的共混物增强了材料的拉伸强度。此双相共混系统互不相容,呈海岛分布。两相间存在界面,易于水的进入和降解的进行,由此带来起始阶段共混材料远快于母体材料的降解。随着降解的进行,PBS和PLA分子链羧基(-COOH)各增加至一定程度,带来相互的自加速降解。
[Abstract]:Polybutylene succinate (PBSs) is one of the fully degradable aliphatic polyester materials developed in recent years. Succinic acid is the intermediate product of human tricarboxylic acid cycle.This becomes the theoretical starting point of its application in human body as a medical material.At present, PBS is an environment-friendly degradable material, which has many advantages, such as good mechanical properties, easy processing and so on.As a medical biomaterial, PBS not only needs to meet the strict requirements of biological safety, but also needs to fully understand the degradation kinetics of PBS in vivo and in vitro.In this study, high purity PBS was obtained by the purification of one-step synthetic PBS. The stimulation and delayed hypersensitivity and the preliminary blood compatibility of the materials were studied in the aspect of biosafety.In the aspect of degradation, the degradation behavior of the materials in simulated environment was studied, and the degradation behavior of the blends reinforced with polylactic polylactic (PLA) was obtained as follows:The purification treatment of 1.PBS has no effect on the properties of PBS, and it can improve the properties of 1.PBS.2.PBS did not stimulate the body, no antigenicity, contact with hemolysis, platelet adhesion close to medical grade PLA material;The degradation mechanism of 3.PBS in the simulated environment is bulk degradation, and the degradation rate changes from fast to slow, the reason is autocatalytic effect, and the transition condition is that the number average molecular weight is reduced to 4 脳 10 4. The degradation begins in amorphous region and then crystallizes.The tensile strength of 4.PBS / PLA blends was enhanced.The two-phase blend system is incompatible and island-distributed.There is an interface between the two phases, which is easy to enter and degrade water, which leads to the degradation of the blending material in the initial stage than that of the parent material.With the degradation of PBS and PLA molecular chain carboxyl groups increased to a certain extent to a certain extent, resulting in self-accelerated degradation of each other.
【学位授予单位】：北京协和医学院
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R318.08

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