三维打印组织工程牙计算机辅助设计建模技术的应用

发布时间：2018-04-09 19:38

本文选题：组织工程　切入点：计算机辅助设计　出处：《中国组织工程研究》2015年38期

【摘要】：背景:国内外关于如何成功构建组织工程牙支架材料内部空间构型的文献报道较少。目的:建立适用于组织工程牙需求的支架材料CAD空间构型及支架结构实体微观模型STL格式文件。方法:采用MICRO CT对离体大鼠第二磨牙进行连续扫描,将MICRO CT获得的DICOM格式文件导入MIMICS软件,将生成的三维模型导入GEOMAGIC12软件,提取外层轮廓,利用偏移功能模拟得到大鼠磨牙外层轮廓数据。利用CATIA V5R17软件构建支架材料空间内部多孔微观模型单体,在空间合适坐标上阵列得到组织工程牙内部支架整体模型,通过变更单体构型还可快速建立多种整体支架构型。装配大鼠磨牙外层轮廓数据与内部空间支架得到三维打印组织工程牙CAD模型STL文件。结果与结论:成功建立了牙体组织支架微观结构CAD模型,该CAD STL模型可直接用于三维打印系统快速成型组织工程牙支架。说明基于结合计算机逆向与正向工程建模技术,可快速建立多种符合组织工程牙要求的支架材料空间构型。
[Abstract]:Background: there are few reports at home and abroad on how to successfully construct the internal spatial configuration of dental scaffolds in tissue engineering.Aim: to establish the STL format file of CAD space configuration and solid model for tissue engineering teeth.Methods: the second molars of isolated rats were continuously scanned by MICRO CT. The DICOM format files obtained by MICRO CT were imported into MIMICS software, and the generated 3D models were imported into GEOMAGIC12 software to extract the outer contour.The outer contour data of rat molars were simulated by migration function.CATIA V5R17 software was used to construct the porous micromodel monomer in the space of the scaffold material, and the whole model of the inner scaffold of the tissue engineering tooth was obtained by the array on the suitable coordinates of the space. By changing the monomeric configuration, a variety of monolithic scaffold configurations could be quickly established.The CAD model STL files of tissue engineering teeth were obtained by assembling the outer contour data of rat molars and the inner space scaffold.Results & conclusion: the CAD model of dental tissue scaffold microstructure was successfully established. The CAD STL model can be directly used in 3D printing system for rapid prototyping of tissue engineering dental scaffolds.It is shown that based on computer reverse and forward engineering modeling technology, many kinds of scaffold materials can be quickly built up in accordance with the requirements of tissue engineering teeth.
【作者单位】：新疆医科大学第一附属医院;
【基金】：国家自然科学基金项目—三维打印构建组织工程化牙槽骨实验研究(81060088) 新疆维吾尔自治区科技支疆项目—三维打印构建复合信号诱导的组织工程牙(201291173)~~
【分类号】：R318.08;TP391.72

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