SH2D7基因及其编码蛋白的生物信息学分析

发布时间：2018-04-14 07:30

本文选题：肿瘤 + SHD　；参考：《科技导报》2015年02期

【摘要】：为了对SH2D7基因序列及其编码蛋白进行生物信息学分析,应用NCBI数据库和Ex PASy等程序,对SH2D7基因核苷酸序列进行了分析,并预测了其编码蛋白的理化性质及二级结构等。结果表明,SH2D7基因定位于人类染色体15q25.1,包含了6个外显子和5个内含子。SH2D7基因编码蛋白的功能主要涉及基因表达调控、信号传导等;分子量约为49.8 k D,等电点为5.99,是一种亲水蛋白,主要位于细胞核中,有35个磷酸化位点及22个抗原位点。
[Abstract]:In order to bioinformatic analysis of SH2D7 gene sequence and its coded protein , the nucleotide sequence of SH2D7 gene was analyzed and the physicochemical properties and secondary structure of SH2D7 gene were predicted . The results showed that SH2D7 gene was located in human chromosome 15q25 . 1 . The function of SH2D7 gene was mainly involved in gene expression regulation , signal transduction , etc . The molecular weight was 49.8 k D , isoelectric point was 5.99 , it was a kind of hydrophilic protein , mainly in nucleus , 35 phosphorylation sites and 22 antigenic sites .

【作者单位】：宁夏医科大学检验学院;宁夏检验医学研究所;
【基金】：宁夏自然科学基金项目(NZ11135)
【分类号】：Q811.4

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