基于聚醚醚酮的骨科植入材料生物相容性研究

发布时间：2018-04-19 04:24

本文选题：骨科植入材料 + 聚醚醚酮　；参考：《基因组学与应用生物学》2017年09期

【摘要】：本研究基于聚醚醚酮的骨科植入材料生物相容性的研究,进一步分析聚醚醚酮(polyether-ether-ketone,PEEK)骨科植入材料生物的相容性能,以有效提高其生物功能性,进而获得更加可靠的骨-植入体界面。本研究通过以新西兰大白兔为研究对象,采用改性/未改性的PEEK材料制备了腰椎模型并植入,最后进行了生物力学与Micro CT分析。实验研究表明,以改性及未改性的PEEK材料制备的腰椎假体在植入动物体内后后,动物体内未发生显著相关的急慢性毒性反应。对比植入的两种PEEK假体我们发现,改性的PEEK腰椎假体在植入动物后第4周,其临近椎骨的植入部位在骨体积分数等参数上发生了明显的改善(p0.05);植入后第8周检查,以骨体积分数(BV/TV)、(骨密度(BMD)、骨小梁厚度(Tb.Th)、骨小梁分离度(Tb.Sp)以及骨表面体积分数(BS/BV)等为代表的多项重要的骨组织形态计量学参数均发生了显著的改善(p0.05)。同时,研究通过采用拔出试验来验证植入材料的生物力学性能,实验发现改性PEEK材料能够有效促进植入假体与椎骨的紧密结合。因此,实验中针对PEEK材料采用rh BMP-2与胶原蛋白对表面进行改性可以高效地、快速地达到效果,并且能够明显提高骨科植入的PEEK材料的生物功能性与生物相容性。
[Abstract]:In this study, the biocompatibility of polyether ether ketone (PEEK) orthopedic implants was studied, and the biocompatibility of polyether ether ketones (PEEK) implants was analyzed.Thus, a more reliable bone-implant interface is obtained.In this study, the lumbar vertebrae model was prepared and implanted with modified / unmodified PEEK material in New Zealand white rabbits. Finally, biomechanics and Micro CT analysis were carried out.The experimental results showed that there was no significant acute or chronic toxic reaction in the lumbar vertebrae prosthesis made of modified or unmodified PEEK material after implanted into the animal body.Comparing the two kinds of PEEK prosthesis, we found that the modified PEEK lumbar vertebra prosthesis had a significant improvement in bone volume fraction and other parameters at the fourth week after implantation, and was examined at the 8th week after implantation.Several important bone histomorphometry parameters, such as bone volume fraction (BV / V) (bone density (BMD), trabecular thickness, trabecular separation, bone trabecular separation, and bone surface volume fraction (BS / BV)), have been significantly improved (p0.05).At the same time, the biomechanical properties of the implants were verified by pull-out test. It was found that the modified PEEK materials could effectively promote the close combination of the implants and the vertebrae.Therefore, using rh BMP-2 and collagen to modify the surface of PEEK materials in the experiment can achieve the effect efficiently and quickly, and can obviously improve the biofunctional and biocompatibility of PEEK materials implanted in orthopedic department.
【作者单位】：新疆医科大学附属中医医院骨一科;
【基金】：新疆医科大学附属中医医院资助
【分类号】：R318.08;R68

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