应用于零维左心血液循环的二尖瓣模型的研究

发布时间：2018-04-19 05:25

本文选题：瓣叶运动流阻模型 + 左心血液循环　；参考：《中国生物医学工程学报》2017年03期

【摘要】：提出一个可以准确合理地模拟二尖瓣动力学特性的瓣叶运动流阻模型。考虑影响二尖瓣瓣叶运动的跨瓣压差和血流推力,建立二尖瓣运动的控制方程,提出依赖于瓣叶打开角度θ的瓣叶运动流阻模型,把该模型应用于零维左心血液循环系统,得到血液动力学特性。在保持心输出量和反流分数一致的条件下,比较该模型、瞬态关闭的阶梯流阻模型和经验指定的时变流阻模型。结果发现,瓣叶运动流阻模型能反映瓣膜关闭过程中的血液动力学,如压差和流量的滞后性以及关闭流量,同时该模型可以通过调整单位转动惯量跨瓣压差影响系数Kp和血流影响系数Kb的大小,改变瓣膜打开过程和关闭过程所需时间,瓣膜打开和关闭时间分别为50.0和40.2 ms。该模型可弥补阶梯流阻模型中忽略瓣膜运动过程的瞬态关闭的缺点,同时也能避免时变流阻模型中关闭起始时间的不合理性。此模型较为合理准确地模拟二尖瓣关闭过程的动力学特性,且简单易控制。
[Abstract]:A flow resistance model of mitral valve motion is proposed, which can accurately and reasonably simulate the dynamic characteristics of mitral valve.Considering the pressure difference and blood flow thrust of mitral valve, the governing equation of mitral valve motion is established, and a flow resistance model of mitral valve motion dependent on lobular opening angle 胃 is proposed. The model is applied to the zero-dimensional left ventricular circulation system.The hemodynamic properties were obtained.Under the condition that the cardiac output and the reflux fraction are consistent, the model, the transient closed step flow resistance model and the empirically specified time-varying resistance model are compared.The results showed that the valve motion resistance model could reflect the hemodynamics during valve closure, such as pressure difference, hysteresis of flow rate and closure flow rate.At the same time, the model can change the opening and closing time of the valve by adjusting the magnitude of the pressure difference of unit moment of inertia and the influence coefficient of blood flow K _ b. The opening and closing time of the valve is 50.0 and 40.2 msrespectively.This model can make up for the shortcoming of neglecting the transient closure of valve movement in the step flow resistance model and avoid the irrationality of the starting time of closure in the time-varying flow resistance model.The model is more reasonable and accurate to simulate the dynamic characteristics of mitral valve closure process, and is simple and easy to control.
【作者单位】：江苏大学流体机械工程技术研究中心;德州理工大学机械工程系;
【基金】：江苏省高层次创新创业人才引进计划基金江苏省江苏特聘教授计划基金江苏省自然科学基金项目(BK20130539)
【分类号】：R318.0

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