生物可降解镁合金血管支架:缺点及未来研究趋势

发布时间：2018-04-20 19:51

本文选题：镁 + 合金　；参考：《中国组织工程研究》2015年08期

【摘要】：背景:可降解支架被认为是血管介入领域继球囊扩张血管成形、金属裸支架、药物洗脱支架后的第4次革新,镁合金支架是目前可降解支架的研发热点。目的:综述可降镁合金血管支架的研究现状,探讨其存在的缺点及研究应用趋势。方法:第一作者用计算机检索PubMed数据库、CNKI相关期刊论文、万方全文数据库2001年1月至2014年11月收录的可降解镁合金血管支架相关研究内容,分析其研究现状及进展。结果与结论:镁合金作为可降解血管支架的体外研究集中在镁合金降解速度、生物相容性及镁合金对血管内皮细胞和平滑肌细胞的影响。目前的研究显示镁合金支架降解过快仍然是限制其大规模临床应用的主要原因,靶血管在置入支架后需要6-12个月的重建修复期,支架应在这段时间内提供机械支撑,现有的可降解镁合金支架尚难以达到这一要求。为提高镁合金支架的耐腐蚀性能及生物相容性,一方面可以考虑选择耐腐蚀性能更好的合金元素,另一方面通过支架涂层等表面改性技术来提高支架的抗腐蚀性能与生物相容性,也是未来镁合金支架研发的一大趋势。
[Abstract]:Background: biodegradable stents are considered to be the fourth innovation after balloon angioplasty, bare metal stents and drug-eluting stents in the field of vascular intervention. Magnesium alloy stents are currently the focus of research and development of degradable stents. Aim: to review the research status of degrade magnesium alloy stent, and discuss its shortcomings and application trend. Methods: the first author searched the full text database of PubMed and Wanfang full text database from January 2001 to November 2014, and analyzed the current situation and progress of the research on the biodegradable magnesium alloy vascular stents. Results and conclusion: the study of magnesium alloy as biodegradable vascular scaffold in vitro focused on the degradation rate biocompatibility of magnesium alloy and the effect of magnesium alloy on vascular endothelial cells and smooth muscle cells. Current research shows that too fast degradation of magnesium alloy stent is still the main reason for limiting its large-scale clinical application. It takes 6-12 months to reconstruct the target vessel after the stent is placed, during which time the stent should provide mechanical support. The existing biodegradable magnesium alloy scaffolds are still difficult to meet this requirement. In order to improve the corrosion resistance and biocompatibility of magnesium alloy scaffolds, on the one hand, the alloy elements with better corrosion resistance can be considered. On the other hand, it is a trend to improve the corrosion resistance and biocompatibility of magnesium alloy scaffolds by surface modification technology such as stent coating.
【作者单位】：中南大学湘雅二医院神经外科;
【分类号】：R318.08

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