介孔二氧化硅纳米粒的医学应用及安全性研究进展

发布时间：2018-04-21 05:03

本文选题：纳米结构 + 生物医学应用　；参考：《中国新药与临床杂志》2017年03期

【摘要】：介孔二氧化硅纳米粒(MSNs)性质优良、易加工修饰,已成为生物医药领域的研究热点。MSNs独特的介孔结构和表面性质,使其能大量、有效地装载药物,并将药物靶向运输、调控释放。MSNs包封或耦合成像探针制得新型造影剂,可在体内实时造影示踪,用于疾病的治疗与诊断。此外,MSNs优异的生物学效应,也使其作为新型支架材料在组织再生工程得以应用。随着MSNs被广泛应用于各领域,其生物安全性愈发受到重视,潜在毒性或将限制其临床应用。本文主要对MSNs在生物医学应用以及安全性评价等方面的研究现状与进展进行综述。
[Abstract]:The mesoporous silica nanoparticles (MSNs) have excellent properties and are easy to process and modify. MSNs have become a research hotspot in the field of biomedicine. MSNs have unique mesoporous structure and surface properties, which enable them to load drugs in large quantities and effectively, and to transport the drugs targeted. A novel contrast agent, which can be used in real-time imaging tracer in vivo, can be used in the treatment and diagnosis of diseases. In addition, MSNs can be used as a new scaffold material in tissue regeneration engineering because of their excellent biological effects. With the wide application of MSNs in various fields, its biological safety has been paid more and more attention, and its potential toxicity may limit its clinical application. In this paper, the research status and progress in biomedical application and safety evaluation of MSNs are reviewed.
【作者单位】：宜春学院医学院基础医学部;
【基金】：国家自然科学基金地区基金项目(81660593) 江西省教育厅科学技术研究项目(GJJ151022)
【分类号】：R318.08

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