组织工程化皮肤:从形态和功能安全替代的前景

发布时间：2018-04-22 02:38

本文选题：组织工程 + 生物相容性材料　；参考：《中国组织工程研究》2017年16期

【摘要】：背景:组织工程学是近年来迅速发展起来的一门新学科,涉及皮肤,角膜、骨、软骨、肌腱等多个领域,组织工程化皮肤为近年年的研究热点,组织工程化皮肤为临床解决皮肤缺损的修复提供了良好的前景。目的:综述近年来组织工程化皮肤研究新进展。方法:由第一作者用计算机检索Medline数据库(1996年至2017年),检索词为"Epidermis;dermis;tissue engineered skin",语言设定英文,从表皮和真皮皮肤替代物对该领域的最新研究现状进行综述,探讨皮肤组织工程目前存在的问题及未来发展方向。结果与结论:纳入文献65篇。复合皮肤替代物虽然包括了表皮与真皮两层结构,但缺乏毛囊、汗腺和皮脂腺等皮肤附属器。如何解决组织工程化皮肤缺少附属器的问题,仍是目前皮肤组织工程研究的热点和重要方向。组织工程化皮肤的构建要在短时间内,生产出能够永久覆盖的皮肤替代物,并可将黑色素细胞和朗格罕氏细胞构建入组织工程皮肤替代物结构中去。现存的生物组织工程皮肤替代物既无法从形态上也无法从功能上完全替代皮肤组织,还需未来进行深入研究。
[Abstract]:Background: tissue engineering is a new subject which has been developed rapidly in recent years. It involves many fields, such as skin, cornea, bone, cartilage, tendon and so on. Tissue engineering skin is a hot topic in recent years. Tissue engineered skin provides a good prospect for clinical repair of skin defects. Objective: to review the recent progress in tissue engineered skin. Methods: the first author searched the Medline database (from 1996 to 2017) with the key word "engineered skin of epidermis tissue". The latest research status in this field was reviewed from epidermis and dermal skin substitutes. To explore the current problems and future development of skin tissue engineering. Results & conclusion: 65 articles were included. Although the composite skin substitute consists of two layers of epidermis and dermis, it lacks skin appendages such as hair follicles, sweat glands and sebaceous glands. How to solve the problem of lack of appendages in tissue engineering skin is still a hot topic and an important direction in skin tissue engineering research. Tissue engineered skin should be constructed in a short time to produce skin substitutes that can be permanently covered, and melanocytes and Langerhans cells can be constructed into tissue engineered skin substitute structures. The existing biological tissue engineered skin substitutes can not completely replace skin tissues in morphology or function, and need further study in the future.
【作者单位】：解放军海军青岛第一疗养院口腔科;解放军海军第401医院崂山分院口腔科;解放军第四军医大学口腔医院;
【基金】：国家自然科学基金(81271104)~~
【分类号】：R318.1

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