银纳米颗粒及载银抗菌涂层的研究与进展

发布时间：2018-04-26 00:31

本文选题：纳米粒 + 银　；参考：《中国组织工程研究》2016年25期

【摘要】：背景:目前大量研究证明银纳米颗粒具有良好的抗菌性能,现已得到广泛应用。目的:从银纳米颗粒的抗菌机制、生物安全性及银纳米抗菌涂层进展等几个方面进行阐述,归纳国内外载银抗菌涂层的研究和发展方向。方法:由第一作者检索1976年1月至2015年1月Web of Science数据库、Pubmed数据库、中国科技期刊数据库(中国知网)中的相关文献,检索关键词为"silver nanoparticles,titanium alloy,implant,antibacterial properties;biosecurity,coating;银纳米颗粒,钛合金,内植物,抗菌性,生物安全性,涂层"。结果与结论:银纳米颗粒以其量子及小尺寸粒子效应,具备极大的比表面积,可很好地与病原微生物密切接触,发挥生物效应,具有优良的抗细菌、真菌、病毒及癌细胞等优点。但其诸多生物效应机制尚不明确,并且银纳米颗粒材料在体内的缓释作用时间、如何控制银离子的缓释仍未解决,长期动物实验也比较少。如何确保银纳米颗粒的长期应用对人体无不良反应,减少其毒性,仍需大量的实验室和临床研究。
[Abstract]:Background: at present, a large number of studies have proved that silver nanoparticles have good antibacterial properties and have been widely used. Aim: to introduce the antibacterial mechanism of silver nanoparticles, biological safety and progress of silver nano-antibacterial coatings, and summarize the research and development trend of silver loaded antibacterial coatings at home and abroad. Methods: from January 1976 to January 2015, the Web of Science database was searched by the first author, and the relevant documents in the database of China Journal of Science and Technology (China Journal of Science and Technology) were searched. The key words were "silver nanoparticlestin titanium alloy simple property biocurity coating. silver nanoparticles, titanium alloy, endophyte, endophyte", and the key words were: "silver nanoparticler titanium alloy, endophyte", "silver nanoparticles, titanium alloy, endophyte, endophyte". Antibacterial, Biosafety, coating. Results & conclusion: silver nanoparticles have great specific surface area due to their quantum and small particle effects, which can be used for close contact with pathogenic microbes and play a biological effect. Silver nanoparticles have excellent antibacterial and fungal properties. Viruses and cancer cells, etc. However, the mechanisms of its biological effects are not clear, and the slow release time of silver nanoparticles in vivo, how to control the slow release of silver ions is still unsolved, and the long-term animal experiments are relatively few. How to ensure the long-term application of silver nanoparticles has no adverse reaction to human body and reduce its toxicity still needs a lot of laboratory and clinical research.
【作者单位】：哈尔滨医科大学附属第一医院;哈尔滨工业大学;
【基金】：博士后科研基金项目(LBZ-Q13124):钛合金抗菌涂层材料预防骨科手术感染的研究黑龙江省教育厅科学技术研究项目(12541344):钛合金复合抗菌涂层材料预防骨科手术感染的研究~~
【分类号】：R318.08

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