老年轻度认知障碍患者的脑电熵分析

发布时间：2018-04-28 19:34

本文选题：轻度认知障碍 + 脑电　；参考：《应用科学学报》2014年06期

【摘要】：选取8名轻度认知障碍(mild cognitive impairment,MCI)老年人和17名正常老年人参与图片颜色的认知任务,并同步记录他们的脑电信号,然后采用相对能量、样本熵和累积残余熵分析方法,研究这两组被试在执行任务时的不同脑区脑电活动的差异.研究发现:1)两组被试alpha相对能量无差异,但MCI患者额中央区和顶枕中央区的脑电熵高于正常人;2)两组被试额区脑电的熵值都高于其他区域,中线区域的脑电熵值低于左右半球;3)刺激类型对两组被试的脑电活动有影响,在完成匹配任务时,两组被试大脑前侧区域的脑电活动更为复杂,并且正常人大脑右侧中央区域的脑电活动复杂性较高;4)与样本熵相比,累积残余熵能更细致地刻画出MCI患者脑电的非线性特征.结果表明,MCI患者认知过程中的脑电活动存在异常,信号更为复杂.与样本熵相比,累积残余熵更适合于分析脑电的非线性特征.
[Abstract]:Eight mild cognitive impairment patients with mild cognitive impairment (MCI) and 17 normal subjects were involved in the cognitive task of image color, and their EEG signals were recorded synchronously. Then the relative energy, sample entropy and cumulative residual entropy were analyzed. To study the difference of EEG activity in different brain regions in the two groups. The study found that there was no difference in the relative energy of alpha between the two groups, but the EEG entropy in the central frontal area and the central parietal occipital area of the MCI patients was higher than that in the normal subjects (2) the entropy of the frontal area in the two groups was higher than that in the other regions. The EEG entropy in the midline region was lower than that in the left and right hemispheres (3)) the type of stimulation had an effect on the EEG activity of the two groups, and when the matching task was completed, the EEG activity in the anterior region of the brain was more complex in the two groups. Compared with the sample entropy, the cumulative residual entropy can describe the nonlinear characteristics of EEG in MCI patients in more detail. The results showed that the EEG activity was abnormal and the signal was more complex in the cognitive process of MCI patients. Compared with the sample entropy, the cumulative residual entropy is more suitable for analyzing the nonlinear characteristics of EEG.
【作者单位】：上海大学通信与信息工程学院;首都医科大学宣武医院;北京市脑功能疾病调控治疗重点实验室;
【基金】：国家自然科学基金(No.61171032) 上海市教委自然科学创新重点项目基金(No.12ZZ099) 北京市重点实验室-脑功能疾病调控治疗实验室开放研究课题基金(No.2013NBTK02)资助
【分类号】：R749.1;R741.044

【共引文献】