编码微载体的制备及其生物医学应用

发布时间：2018-05-01 21:07

本文选题：编码微载体 + 编码策略　；参考：《化学进展》2017年10期

【摘要】：高通量分析技术在生物检测、药物递送、材料评估和防伪等方面有着重要的应用,这些应用通常依赖于多元分析来实现。编码微载体技术为多元分析提供了一个可行的策略。编码微载体通过赋予不同微载体不同编码信息来实现编码,编码方式通常为图形编码、光学编码等的一种或多种,并通过每个微载体编码信息的不同来实现对生物分子、细胞和材料的区分和检测。本文总结了编码微载体领域的研究进展,介绍了微载体常用的编码策略,并重点阐述了基于编码微载体的分析技术在多元检测、细胞培养与捕获、药物评估、药物递送和防伪等领域的应用。最后,我们总结了编码微载体的优缺点,并对其发展前景进行了展望。
[Abstract]:High-throughput analytical techniques have important applications in biological detection, drug delivery, material evaluation and anti-counterfeiting. These applications usually rely on multivariate analysis. Coding microcarrier technology provides a feasible strategy for multivariate analysis. Coding microcarriers encode by giving different coding information to different microcarriers, usually one or more of the graphic coding, optical coding, and so on, and through the different encoding information of each microcarrier to achieve the biological molecules. Differentiation and detection of cells and materials. This paper summarizes the research progress in the field of coded microcarriers, introduces the common coding strategies of microcarriers, and focuses on the analysis technology based on coded microcarriers in multivariate detection, cell culture and capture, drug evaluation. Drug delivery and anti-counterfeiting applications. Finally, we summarize the advantages and disadvantages of the coding microcarriers and prospect their development prospects.
【作者单位】：东南大学生物电子学国家重点实验室;哈佛大学工程与应用科学学院;东南大学苏州研究院苏州市环境与生物安全重点实验室;
【基金】：国家自然科学基金项目(No.21473029,51522302) NSAF基金项目(No.U1530260) 东南大学优秀博士学位论文培育基金资助~~
【分类号】：R318

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