壳聚糖支架材料在组织工程中的应用与未来

发布时间：2018-05-04 11:33

本文选题：壳聚糖 + 支架　；参考：《中国组织工程研究》2017年30期

【摘要】：背景:壳聚糖作为功能性高分子材料已被广泛应用于生物医药领域,是具有传感功能、反馈功能和响应功能的智能材料。目的:综述近年壳聚糖支架材料在组织工程不同领域内的应用,并着重介绍壳聚糖作为支架材料所具备的优势和劣势。方法:以"组织工程,支架材料,壳聚糖;tissue engineering,scaffold,chitosan"为关键词,检索CNKI、PubMed数据库2000至2016年的文献,将所有文章进行初步筛选后,对保留的文章进一步详细分析、归纳并总结。结果与结论:壳聚糖支架生物相容性好,能在体内降解,同时能携载许多不同的生长因子,目前已在神经组织工程、眼角膜组织工程、牙周组织工程、软骨组织工程、骨组织工程、皮肤组织工程、心肌组织工程等方面有了广泛应用。但随着科技的进步,组织工程支架有利于组织修复的机制仍然存在许多争议。将壳聚糖与其他材料复合可形成仿生程度越来越高的人工细胞外基质,拓宽了壳聚糖的应用范围。
[Abstract]:Background: chitosan, as a functional polymer material, has been widely used in biomedical field. It is a smart material with sensing function, feedback function and response function. Aim: to review the applications of chitosan scaffolds in different fields of tissue engineering in recent years, and to introduce the advantages and disadvantages of chitosan as scaffolds. Methods: using "tissue engineering, scaffold material, chitosan tissue engineering scaffold chitosan" as the key word, the literature of CNKI PubMed database from 2000 to 2016 was searched. After the preliminary screening of all articles, the retained articles were further analyzed, summarized and summarized. Results & conclusion: chitosan scaffolds have good biocompatibility, biodegradation in vivo and many different growth factors. At present, chitosan scaffolds have been used in nerve tissue engineering, corneal tissue engineering, periodontal tissue engineering, cartilage tissue engineering. Bone tissue engineering, skin tissue engineering and myocardial tissue engineering have been widely used. However, with the development of science and technology, the mechanism of tissue engineering scaffold is still controversial. When chitosan was combined with other materials, the artificial extracellular matrix with higher and higher biomimetic degree could be formed, which widened the application of chitosan.
【作者单位】：大连理工大学盘锦校区生命与医药学院;
【基金】：中央高校基本科研业务费专项资金资助(DUT16RC(4)73) 辽宁省教育厅科学研究一般项目(L2015111)~~
【分类号】：R318.08

【相似文献】