聚焦超声辐照兔眼角膜的生物效应研究

发布时间：2018-05-05 08:56

本文选题：聚焦超声 + 兔　；参考：《重庆医科大学学报》2014年05期

【摘要】：目的:利用聚焦超声(focused ultrasound,FU)热效应对兔眼角膜进行辐照,观察其生物效应的变化。方法:13只新西兰兔(26眼)根据辐照功率及辐照角膜直径的不同随机分为A、B、C组。设计A组辐照功率为1 W,辐照角膜直径为9 mm;B组辐照功率为1.5 W,辐照角膜直径为9 mm;C组辐照功率为1 W,辐照角膜直径为7 mm。分别于术前及术后3、10 d、1月、2、3月对术眼进行裂隙灯、自动验光仪、角膜地形图、内皮细胞计数仪及非接触眼压的检查及记录。结果:术后即刻24眼(92.3%)角膜辐照区上皮缺损,术后3 d 26眼(100%)角膜上皮完整。角膜中央曲率于术后1月开始降低,随观察时间延长呈逐渐降低趋势;屈光度术后呈正向增加趋势,向远视方向发展,与角膜中央曲率变化趋势一致。非接触眼压术后3、10 d降低,术后1、2、3月恢复到术前水平。角膜内皮细胞计数术前术后无明显变化。结论:辐照兔眼周边角膜引起角膜中央曲率降低。FU应用于兔眼角膜安全性较高。
[Abstract]:Aim: to observe the effect of focused ultrasound (FU) on rabbit cornea. Methods Twenty-six eyes of 13 New Zealand rabbits were randomly divided into two groups according to irradiation power and corneal diameter. The radiation power of group A was 1 W, the diameter of irradiated cornea was 1.5 W in group B, the power of group C was 1 W, and the diameter of irradiated cornea was 7 mm. Slit-lamp, automatic optometry, corneal topography, endothelial cell counter and non-contact intraocular pressure were examined and recorded before and 3 days after operation. Results: immediately after operation, 24 eyes (92.3%) had epithelial defect in irradiated area, and 26 eyes (100 eyes) had complete corneal epithelium 3 days after operation. The central curvature of cornea began to decrease in the first month after operation and gradually decreased with the prolongation of observation time, and the diopter showed a positive trend to increase and to develop to hyperopia, which was consistent with the change trend of central curvature of cornea. The non-contact IOP decreased at 3 ~ 10 days postoperatively and recovered to the preoperative level at 1 and 2 days postoperatively. There was no significant change in corneal endothelial cell count before and after operation. Conclusion: the central curvature of the cornea induced by irradiating the peripheral cornea of rabbit eyes is decreased. FU is a safe method for the treatment of rabbit cornea.
【作者单位】：重庆医科大学附属第二医院眼科中心;重庆明达眼科;
【基金】：重庆市卫生局重点课题(编号:2010-1-25)
【分类号】：R310

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