一种新型血管支架用无镍钴基合金

发布时间：2018-05-11 06:31

本文选题：血管支架 + 无镍　；参考：《稀有金属材料与工程》2014年S1期

【摘要】：目前临床上使用钴铬钨镍合金(L605)的高强度特性保证支架网丝直径较传统支架降低30%左右,平均直径在80μm左右,有效减小了支架对内膜组织的刺激,减少了支架再狭窄的潜在诱因,临床疗效明显。但是L605合金和传统的316L不锈钢一样,其中含有10%左右的镍元素。大量临床研究表明,镍有致敏、致癌和诱发血栓等毒副作用,而且镍离子对血管内膜的过敏刺激反应以及其与再狭窄的相互关系一直存在争议。针对传统医用钴基合金中潜在的镍离子危害,研究开发了一种新型血管支架用无镍钴基合金Co-20Cr-12Fe-18Mn-2Mo-4W-N,通过补充人体必需微量元素铁Fe和锰Mn元素来替代部分昂贵钴元素。和传统的L605合金相比,新型无镍钴基合金的抗拉强度达到1000 MPa以上,延伸率达到55%以上。同时新型无镍钴基合金具有优良的耐蚀性能,点蚀电位高达1000 mV以上。新型无镍钴基合金优良的强韧性和耐蚀性,有望成为新一代血管支架材料。
[Abstract]:At present, the high strength characteristic of Cobalt-Cr-W-Ni alloy (L605) ensures that the diameter of the mesh wire decreases by about 30% and the average diameter is about 80 渭 m compared with the traditional stent, which effectively reduces the stimulation of the stent to the endometrial tissue. The potential inducement of stent restenosis is reduced, and the clinical effect is obvious. But the L605 alloy, like the conventional 316L stainless steel, contains about 10% nickel. A large number of clinical studies have shown that nickel has toxic side effects, such as sensitization, carcinogenesis and thrombosis, and the allergic response of nickel ion to vascular intima and its relationship with restenosis have been controversial. In view of the potential nickel ion hazards in traditional medical cobalt-based alloys, a new nickel-free cobalt-based alloy Co-20Cr-12Fe-18Mn-2Mo-4W-N for vascular stents was developed. Some expensive cobalt elements were replaced by supplementation of the necessary trace elements Fe Fe and mn to replace some expensive cobalt elements. Compared with the traditional L605 alloy, the tensile strength and elongation of the new Nickel-Cobalt base alloy are over 1000 MPa and 55%, respectively. At the same time, the new nickel-free cobalt-base alloy has excellent corrosion resistance, the pitting potential is over 1000 MV. New nickel-free cobalt-based alloys are expected to be a new generation of vascular scaffolds due to their excellent strength and corrosion resistance.
【作者单位】：中国科学院金属研究所;
【基金】：国家自然科学基金(31370976) 国家重点基础研究发展计划“973”(2012CB619101)
【分类号】：R318.08

【共引文献】