骨髓间充质干细胞在多种疾病治疗中的应用进展

发布时间：2018-05-11 10:16

本文选题：骨髓 + 间质干细胞　；参考：《中国组织工程研究》2017年21期

【摘要】：背景:骨髓间充质干细胞是来源于中胚层的非造血干细胞,主要取材于骨髓,其有着较强的自我更新能力、多向分化能力以及低免疫原性,易于接受外源基因的导入,是近些年研究应用的热点。目的:综述骨髓间充质干细胞在各疾病中的研究与应用进展。方法:由第一作者检索2011至2016年Pub Med数据库(http://www.ncbi.nlm.nih.gov/PubM ed)及中国生物医学文献数据库(http://www.sinomed.ac.cn/zh/),中文检索词为"骨髓间充质干细胞、治疗",英文检索词为"bone marrow mesenchymal stem cells,therapy"。排除重复性研究或Meta分析类文章,共保留其中的49篇文献进行归纳总结。结果与结论:骨髓间充质干细胞在呼吸系统疾病、心血管疾病、泌尿系统疾病、神经系统疾病、肝脏疾病、糖尿病、血液系统疾病、自身免疫性疾病和移植物抗宿主病、运动系统疾病等方面均有了新的研究与应用进展,但其应用仍有致瘤性风险。随着对其深入研究,骨髓间充质干细胞的致瘤等相关问题将逐步得到解决,从而更好地应用于临床。
[Abstract]:Background: bone marrow mesenchymal stem cells (BMSCs) are non-hematopoietic stem cells derived from mesoderm. They are mainly derived from bone marrow. They have strong ability of self-renewal, multidirectional differentiation and low immunogenicity. It is a hot research and application in recent years. Objective: to review the research and application of bone marrow mesenchymal stem cells in various diseases. Methods: the first author searched the Pub Med database http1: / www.ncbi.nlm.nih.gov.PubMed from 2011 to 2016 and the Chinese biomedical literature database http: / www.sinomed.ac.cn.cnr.zhr.Chinese key words were "bone marrow mesenchymal stem cells, therapy", and the English key word was "bone marrow mesenchymal stem cell therapy." Excluding repetitive research or Meta analysis articles, 49 of them were retained for summarization. Results and conclusion: bone marrow mesenchymal stem cells were found in respiratory diseases, cardiovascular diseases, urinary system diseases, nervous system diseases, liver diseases, diabetes mellitus, blood system diseases, autoimmune diseases and graft-versus-host diseases. New research and application progress have been made in sports system disease, but its application still has tumorigenic risk. With the further study, the tumorigenicity of bone marrow mesenchymal stem cells and other related problems will be solved step by step, so as to be better applied in clinical practice.
【作者单位】：天津医科大学研究生院;天津市天津医院微创脊柱外科;
【基金】：国家自然科学基金资助项目(81272046) 天津市卫生局攻关课题(14KG121,15KG125) 天津市科学技术委员会课题(15JCYBJC25300)~~
【分类号】：R318

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