类竹鼠牙釉质含铁羟基磷灰石的仿生合成与性能研究

发布时间：2018-05-14 13:45

本文选题：竹鼠红色牙釉质 + Fe-HA　；参考：《西南交通大学》2017年硕士论文

【摘要】：包括人在内的大多数哺乳动物牙齿内的无机相均为羟基磷灰石,遗憾的是,现阶段,羟基磷灰石陶瓷很少用作牙科修复材料,这主要归因于其脆性大和力学性能差的问题没有得到很好的解决。同时,纳米HA颗粒的微观结构、结晶形态及掺杂改性等方面还有待于进一步研究。已有文献表明,相比于人牙,竹鼠牙釉质显示出更高硬度、更好的耐磨性和耐酸蚀能力。因此,本研究通过仿生合成与天然牙釉质类似的羟基磷灰石,有望提高羟基磷灰石的综合性能,扩展其在牙科修复材料方面的应用。本文以竹鼠切牙表面红色釉质作为仿生对象,采用多种分析测试手段,表征分析了竹鼠切牙釉质内羟基磷灰石的微观结构以及成分组成。在此基础上,以Ca(NO_3)_2·4(H_2O)、Fe(NO_3)_3·9(H_2O)和(NH_4)_2HPO_4为原料,利用超声辅助微波水热合成法制备类竹鼠牙釉质含Fe羟基磷灰石(Fe-HA),研究了 Fe含量对合成Fe-HA物相组成、晶体结构和微观形貌的影响,并进一步表征了 Fe含量对Fe-HA复合生物陶瓷显微硬度、耐酸蚀性能、摩擦学性能以及抗菌性能的影响。1)竹鼠红色牙釉质内的无机相主要为含Fe羟基磷灰石,Fe的相对含量约为6.08 wt%;含Fe羟基磷灰石晶体为短棒状,长度约100 nm,直径约20 nm,其择优生长晶面为(002)。2)采用超声辅助微波水热合成法制备了缺钙型Fe-HA纳米颗粒,其含有少量的CO_3~(2-),晶粒尺寸均匀,结晶度较低,与竹鼠牙釉质HA结构类似。Fe含量对Fe-HA的形貌和晶体结构具有较大的影响,其中,Fe含量为1.5 wt%时,所制备的HA晶粒结晶度最佳,呈短棒状,长度约100 nm,直径约15 nm。3)往复滑动磨损试验、浸泡试验和细菌试验结果显示,相对于纯HA陶瓷,Fe1.5 wt%-HA生物陶瓷具有优异的机械性能(高硬度和高耐磨性)、更好的耐酸蚀能力及较优的抗菌性能。
[Abstract]:The inorganic phases in most mammalian teeth, including human beings, are hydroxyapatite. Unfortunately, hydroxyapatite ceramics are rarely used as dental restoration materials at this stage. The main reason is that the problems of high brittleness and poor mechanical properties have not been solved well. At the same time, the microstructure, crystalline morphology and doping modification of HA nanoparticles need to be further studied. Compared with human teeth, the enamel of bamboo rodents shows higher hardness, better wear resistance and acid corrosion resistance. Therefore, the synthesis of hydroxyapatite similar to natural enamel is expected to improve the comprehensive properties of hydroxyapatite and expand the application of hydroxyapatite in dental restoration. In this paper, the surface red enamel of bamboo rat incisors was used as biomimetic object, and the microstructure and composition of hydroxyapatite in enamel of bamboo rat incisor were characterized and analyzed by various analytical methods. On this basis, the effects of Fe content on the phase composition, crystal structure and microstructure of synthetic Fe-HA enamel were studied by using Ca(NO_3)_2 _ 4H _ 2O _ 2 and NH _ 4S _ 2HPO _ 4 as raw materials. The effect of Fe content on the microhardness and acid corrosion resistance of Fe-HA composite bioceramics was further characterized. Effects of tribological and antibacterial properties. 1) the inorganic phase in red enamel of bamboo rat is mainly composed of the relative content of Fe hydroxyapatite and the relative content of Fe in the enamel is about 6.08 wt. the crystal of Fe-containing hydroxyapatite is in the shape of a short rod. Calcium deficient Fe-HA nanoparticles were prepared by ultrasonic assisted microwave hydrothermal synthesis method. The nanocrystals containing a small amount of CO _ 3O _ 3O _ 2-O _ (2) have uniform grain size and low crystallinity, and the crystal size is uniform, and the crystallinity is low, the length is about 100 nm and the diameter is about 20 nm. The morphology and crystal structure of Fe-HA were greatly affected by the content of .Fe, which was similar to the HA structure of the enamel. When the content of Fe was 1.5 wt%, the crystallinity of HA was the best with short rod shape. About 100 nm in length and 15 nm.3 in diameter) reciprocating sliding wear test, immersion test and bacterial test show that, Compared with pure HA ceramics, Fe1.5 wt%-HA bioceramics have excellent mechanical properties (high hardness and high wear resistance), better acid corrosion resistance and better antibacterial properties.
【学位授予单位】：西南交通大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R783.1

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