内耳前庭半规管平衡机制生物力学模型研究

发布时间：2018-05-16 11:14

本文选题：前庭半规管 + 椭圆囊内淋巴阀　；参考：《大连理工大学》2013年博士论文

【摘要】：人内耳前庭系统在维持身体平衡中起着先导作用。但是由于内耳埋藏位置深,结构复杂而精细,导致前庭常见疾病的病因和发病机制尚需明确,前庭功能检查定侧和定位上的诊断还缺乏有效手段,前庭疾病的治疗多限于对症。前庭系统功能异常和病理变化以及过度的外界环境激励是诱发眩晕的重要原因,严重影响了人们的生活质量。对于飞行员等特殊职业人员眩晕是导致飞行事故的重要因素。生物力学因素在内耳前庭系统行使平衡功能的过程中起着重要作用,其中前庭半规管感受头位有角运动依赖于管中内淋巴液的流动和嵴顶形变之问的相互作用和一个机电传导过程。将力学的基本原理与方法应用于人内耳前庭系统结构与平衡机制的相关性研究,可为探讨眩晕病症与内耳结构的相关性,提高前庭功能检查定侧、定位诊断敏感性,寻找有效治疗方法等提供定量依据。本文主要工作包括： 1、通过对豚鼠内耳结构的研究,获得豚鼠内耳结构三维重建的有效方法。在此基础上,根据一例正常人内耳前庭半规管结构的数据,对其几何结构进行三维重建。采用有限元法对该半规管内淋巴液——嵴顶耦合系统进行了模态分析,得到系统的基频为13.46Hz,远高于人日常自然活动频率以及临床旋转试验和冷热试验的检查频率。 2、进行了体位变化激励下人双耳前庭半规管平衡机制的数值分析。结果表明,头绕对称轴水平正弦转动或左右正弦滚转时,左右耳对称半规管的力学响应幅值相等,相位相差3.14rad,使得对称半规管的刺激强弱相反：头前后正弦翻转时,双耳对称半规管的力学响应幅值和相位均相等,使得对称半规管的刺激强弱相同。由此推断任意头位变化,通过前庭眼反射,双耳前庭半规管中的力学响应将诱发双眼向相同的方向等幅度转动,维持视网膜成像的稳定。 3、对健康人双耳前庭半规管在人自然活动频率范围头水平转动进行了频率特性分析,寻找前庭半规管振动的特异性。研究发现水平半规管嵴顶椭圆囊侧表面的振动幅值对转动加速度较敏感,而管侧表面对转动速度较敏感,嵴顶振动的相位只与外载荷频率相关。随着外界载荷频率增大,水平半规管嵴顶两侧的振动幅值和相位差均增大。根据这一特异性,可以通过临床旋转试验定位评估水平半规管功能。 4、进行了环境温度激励下人双耳前庭半规管平衡机制的数值分析。结果表明在外耳道口持续灌注冷热水或气,水平半规管被激励约20s后,前半规管才被稳定激励；约40s后,后半规管被稳定激励。推测临床Hallpike冷热试法对前后半规管功能的评估不可靠。为了通过冷热试法可靠地评定前后半规管的功能,需要延长在外耳道口灌注冷热水或气的时间,这个规律适用于任何头位冷热试验评定前庭半规管功能。 5、探讨了椭圆囊内淋巴阀在人内耳前庭半规管平衡机制中的作用,对尚未明确的椭圆囊内淋巴阀的功能进行了探索。椭圆囊内淋巴阀张开后,任意头位变化,会使得内耳膜迷路上部和下部的内淋巴液体积不等量交换。如果体位变化激励越大,椭圆囊内淋巴阀的开口面积越大,通过开口交换的内淋巴液的体积将越多,对嵴顶变形运动的影响会越大,从而影响半规管的平衡机制。本文研究结果表明,椭圆囊内淋巴阀在前庭半规管行使平衡功能的过程中起着重要作用,如果其功能异常,可能增加梅尼埃病和良性阵发性位置性眩晕等前庭疾病的发生几率。
[Abstract]:The vestibular system plays an important role in maintaining body balance . However , because of the deep buried depth and complicated structure of the inner ear , the etiology and pathogenesis of vestibular disorders need to be clarified .

1 . Based on the study of the inner ear structure of guinea pig , the effective method of three - dimensional reconstruction of the inner ear structure of guinea pig was obtained . On the basis of this , the geometric structure was reconstructed by using the data of the semicircular canal structure of the inner ear of a normal person . The frequency of the system was 13.46 Hz , which was much higher than that of the human daily natural frequency and the frequency of clinical rotation test and cold - heat test .

The results show that the mechanical response amplitude and phase of the symmetric semi - regulation tube are equal , the phase difference is 3.14rad , the mechanical response amplitude and the phase of the symmetric semi - regulation tube are equal to each other , so that the stimulus of the symmetric semi - regulation tube is the same .

The results showed that the amplitude of the vibration amplitude on the lateral surface of the horizontal semicircular canal was sensitive to the rotational acceleration , while the phase of the crest vibration was only correlated with the frequency of the external load .

4 . The numerical analysis of the balance mechanism of the vestibular semicircular canal at ambient temperature was carried out . The results showed that cold or hot water or gas was continuously infused at the external auditory canal , and the front semi - regulation tube was excited about 20s after the horizontal semicircular canal was excited about 20s ;
In order to evaluate the function of the anterior and posterior semicircular canal reliably by means of cold - hot test , it is necessary to prolong the time of cold - hot water or gas filling at the mouth of the external ear canal . This rule is applicable to the evaluation of the vestibular semicircular canal function in any head - position cold - heat test .

5 . The function of the lymphatic valve in the anterior vestibular semicircular canal was discussed . After the expansion of the lymphatic valve in the oval capsule , the larger the opening area of the lymphatic valve in the oval capsule , the larger the opening area of the lymphatic valve in the oval capsule , the greater the volume of the inner lymphatic fluid exchanged by the opening , the greater the volume of the inner lymphatic fluid exchanged by the opening , the greater the volume of the inner lymphatic fluid exchanged by the opening , the greater the volume of the inner lymphatic fluid through the opening , the greater the volume of the inner lymphatic fluid through the opening , and the greater the probability of occurrence of vestibular diseases , such as meloniere ' s disease and benign paroxysmal positional vertigo .

【学位授予单位】：大连理工大学
【学位级别】：博士
【学位授予年份】：2013
【分类号】：R318.01

【参考文献】