骨形态发生蛋白2载体材料在脊柱融合方面的研究与应用

发布时间：2018-05-16 13:36

本文选题：骨形态发生蛋白质类 + 脊柱融合术　；参考：《中国组织工程研究》2015年52期

【摘要】：背景:骨形态发生蛋白2在临床中单独应用存在一些不良反应,因此迫切需要研制理想的载体材料,来减少骨形态发生蛋白2引起的不良反应。目的:全面了解不同骨形态发生蛋白2载体材料的性能,综述其在脊柱融合方面的研究进展。方法:以"tissue engineering,Bone morphogenetic protein-2,spinal fusion,scaffold"或"组织工程,骨形态发生蛋白2、脊柱融合、支架"等作为检索词,由第一作者检索Pub Med及万方数据库1995-07-01/2015-07-01有关脊柱融合中骨形态发生蛋白2支架方面的文献,排除重复性研究。结果与结论:骨形态发生蛋白2的载体材料主要包括4大类,天然生物材料、人工合成有机材料、人工合成无机材料及复合材料,每一类都有几种代表性的支架材料,用于动物脊柱融合中各有缺点,比如天然生物材料普遍力学性能较差,人工合成有机材料有可能引起炎症反应,人工合成无机材料机械强度较差,复合支架材料制作工艺较复杂等,因此骨形态发生蛋白2载体材料的选择仍需进一步的实验研究。
[Abstract]:Background: there are some adverse reactions in clinical application of bone morphogenetic protein-2 alone, so it is urgent to develop an ideal carrier material to reduce the adverse reactions caused by bone morphogenetic protein-2. Objective: to investigate the properties of different bone morphogenetic protein 2 carriers and to review their advances in spinal fusion. Methods: "tissue engineering bone morphogenetic protein-2 spinal fusion scaffold" or "tissue engineering, bone morphogenetic protein 2, spinal fusion, scaffold" were used as key words. The literature on bone morphogenetic protein-2 scaffolds in spinal fusion was searched by Pub Med and Wanfang database 1995-07-01 / 2015-07-01, excluding repetitive studies. Results and conclusion: the carrier materials of bone morphogenetic protein-2 mainly include four categories, natural biomaterials, synthetic organic materials, synthetic inorganic materials and composite materials, each of which has several representative scaffold materials. For example, natural biomaterials generally have poor mechanical properties, synthetic organic materials may cause inflammatory reactions, and synthetic inorganic materials have poor mechanical strength. The fabrication process of composite scaffold is complex, so the selection of bone morphogenetic protein 2 carrier material needs further experimental study.
【作者单位】：苏州大学附属第一医院骨科;
【基金】：国家自然科学基金项目(K112228613):应用改性丝素蛋白共价枝接BMP-2寡肽促进脊柱融合的实验研究~~
【分类号】：R318.08

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