两种钛合金成品表面特性表征及血液相容性的对比研究

发布时间：2018-05-17 14:18

本文选题：钛合金 + 血液相容性　；参考：《山西医科大学》2016年硕士论文

【摘要】：目的:对两种不同加工工艺生产的钛合金成品(白色和黑色)进行表面特性鉴定,并评价其血液相容性,为选择合适的工艺流程提供理论依据。方法:使用扫描电子显微镜(SEM)、能谱分析(EDS)、原子力显微镜(AFM)、X射线衍射仪(XRD)、X射线光电子能谱仪(XPS)对两种钛合金的表面结构、表面物理和化学性能进行表征。通过体外纤维蛋白原吸附、血小板粘附与激活、凝血时间的测定等实验,以及体内植入狗右心房10日观察血栓形成情况,系统评价两种钛合金的血液相容性。结果:白色钛合金表面为粗且深的犁沟,成分为Ti、Al、V,黑色钛合金表面呈孔样层状叠加分布,且成分除了Ti、Al、V外,还有Si、Na、Ca、Fe等杂质。XRD结果显示两种钛合金物相结构均为钛。XPS结果显示两种钛合金表层都形成极薄的TiO2薄膜,但黑色钛合金形成的TiO2薄膜略厚于白色钛合金。体外纤维蛋白原吸附、血小板粘附与激活及凝血时间结果均显示两种钛合金血液相容性无明显差异。体内植入实验结果显示两种钛合金表面均形成了血栓,但黑色钛合金有明显异物反应,形成了增生的肉芽组织,且电镜下显示的表面粘附的有形成分为白色钛合金少于黑色钛合金。结论:结合体内体外实验,白色钛合金生物相容性优于黑色钛合金。
[Abstract]:Objective: to identify the surface properties of titanium alloy products (white and black) produced by two different processing processes, and to evaluate their blood compatibility, and to provide theoretical basis for selecting suitable technological process. Methods: the surface structure, surface physical and chemical properties of the two titanium alloys were characterized by scanning electron microscopy (SEM), energy spectrum analysis (EDS) and atomic force microscopy (AFM). In vitro fibrinogen adsorption, platelet adhesion and activation, measurement of coagulation time, and in vivo implantation of dog right atrium for 10 days were used to observe thrombosis, and the blood compatibility of the two titanium alloys was systematically evaluated. Results: the surface of white titanium alloy was thick and deep ploughing, and the composition of the white titanium alloy was Tijiaal (V). The surface of the black titanium alloy was distributed as a porous layered superposition. The results also show that the phase structure of the two titanium alloys is titanium. The results show that the thin TiO2 films are formed on the surface of the two titanium alloys, but the TiO2 films formed by the black titanium alloys are slightly thicker than that of the white titanium alloys. The results of fibrinogen adsorption, platelet adhesion and activation in vitro and coagulation time showed that there was no significant difference in blood compatibility between the two titanium alloys. The results of implanted experiments in vivo showed that thrombus was formed on the surface of both titanium alloys, but the black titanium alloy had obvious foreign body reaction and formed hyperplastic granulation tissue. The visible component of surface adhesion was less white titanium alloy than black titanium alloy under electron microscope. Conclusion: the biocompatibility of white titanium alloy is superior to that of black titanium alloy in vivo and in vitro.
【学位授予单位】：山西医科大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R318.08

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