血管脉动对骨单元内液体流动行为的影响

发布时间：2018-05-19 09:41

  本文选题：骨单元 + 血管脉动　； 参考：《生物医学工程学杂志》2017年05期

【摘要】：骨组织内部存在两大类液体,一类是血液,一类是间隙流。骨细胞新陈代谢主要依赖于间隙流微环境。在骨组织的微观结构下,骨单元壁中液体的渗流行为是研究的热点。本文的主要目的是考察中央哈弗管的血管脉动对骨单元壁中的间隙流流动行为的影响。本文利用COMSOL Multiphysics软件分别建立了中空的和考虑哈弗管中血管脉动的骨单元多孔弹性力学有限元模型,并对比了轴向载荷下两种模型中骨单元壁中的液体渗流行为。结果表明:当考虑哈弗管中的血管脉动时,骨单元壁中液体的压力会明显增大,而流速几乎没有影响。具体地,骨单元孔隙组织液的压力幅值随着血压脉动幅值的增大而增大,受脉动频率的变化影响不大,而血压脉动幅值及频率对骨单元孔隙组织液的流速基本没有影响。该有限元模型可用来进一步研究非轴对称载荷及微裂缝等复杂应力状态下骨单元的多孔弹性力学行为,并为研究骨的力传导及力-电传导机制提供新方法。
[Abstract]:There are two kinds of fluid in bone tissue, one is blood and the other is interstitial flow. The metabolism of bone cells mainly depends on interstitial flow microenvironment. Under the microstructure of bone tissue, the seepage behavior of fluid in bone cell wall is a hot topic. The main purpose of this paper is to investigate the effect of vascular pulsation of the central Hafer tube on the flow behavior of the interstitial flow in the bone unit wall. In this paper, the finite element model of porous elastic mechanics of bone element is established by using COMSOL Multiphysics software, and the fluid seepage behavior of bone element wall in two models under axial loading is compared. The results show that the pressure of the fluid in the bone unit wall increases obviously when the vessel pulsation in the Hafer tube is taken into account, but the flow rate has little effect on the flow rate. Specifically, the pressure amplitude of bone unit pore tissue increased with the increase of blood pressure pulsation amplitude, and was not affected by the fluctuation frequency, but the blood pressure fluctuation amplitude and frequency had no effect on the flow rate of bone unit pore tissue fluid. The finite element model can be used to further study the porous elastic behavior of bone elements under complex stresses such as non-axisymmetric loads and micro-cracks, and provide a new method for the study of force conduction and force-electric conduction mechanism of bone.
【作者单位】： 太原理工大学力学学院材料强度与结构冲击山西省重点实验室;
【基金】：国家自然科学基金(11632013,11472185,11702183) 山西自然科学基金(2016021145) 山西省高等学校创新人才支持计划资助项目(143230146-S) 山西省高等学校科技创新项目(2014116,2017135) 大连理工大学精细化工国家重点实验室开放课题基金项目(KF1511)
【分类号】：O35;R318.01
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本文编号：1909612