小口径人工血管的快速激光加工研究

发布时间：2018-05-23 18:41

本文选题：小口径人工血管 + 自发图案化　；参考：《吉林大学》2012年硕士论文

【摘要】：小口径人工血管由于其生物相容问题影响远期通畅率，而在临床应用中受到限制。小口径人工血管制备及仿生结构化也是科研的重点所在。本论文采用旋转曝光法可快速制备不同口径的人工血管，并采用自发和激光加工相结合的方法在血管内外壁进行了仿生结构化。首先我们利用聚乙二醇二丙烯酸酯和聚乙二醇的混合溶液作为前聚体溶液，利用旋转曝光的方法制备了聚合物管。将光线精确聚焦在可旋转、透明的装有高分子预聚体系的圆筒模具的内壁处，然后在控制模具转动的同时，利用紫外聚合的方法对聚合物溶液体系按照轴向进行可控光聚合加工，当聚合物管厚度达到一定数值的时候，停止光照，即可得到聚合物管。管径为4mm，壁厚约为0.4mm，拉伸强度为0.50MPa。外表面具有粗糙的表面结构，，而内表面平滑有利于激光加工。这种方法简单快速可批量生产，并且通过调节不同参数可以得到不同尺寸的人工血管。文中首次采用自发与激光加工相结合的方法来实现血管内外壁的仿生结构化。聚合物管经溶胀-干燥后，在外管壁形成与轴向平衡的“沟槽”褶皱图案，这种褶皱的特征尺寸可在101-103μm之间调节。内表面利用飞秒激光放大器进行二维“岛类”或“沟槽”的仿生微纳加工。这种方法制备的小口径人工血管不但具有仿生的内外表面微结构并且具有良好的生物相容性。
[Abstract]:The long-term patency of small-caliber artificial vessels is limited in clinical application because of its biological compatibility. The preparation and biomimetic structure of small-caliber artificial blood vessels are also the focus of scientific research. In this paper, rotating exposure method can be used to rapidly fabricate different caliber artificial blood vessels, and the bionic structure of the inner and outer walls of blood vessels is carried out by the combination of spontaneous and laser processing. Firstly, the polymer tube was prepared by rotating exposure using the mixed solution of polyethylene glycol diacrylate and polyethylene glycol as the prepolymer solution. Accurately focus the light on the inner wall of a cylindrical mould with a rotatable, transparent polymer prepolymer system, and then control the mold rotation, The polymer solution was processed by controlled photopolymerization according to axial direction by ultraviolet polymerization. When the thickness of the polymer tube reached a certain value, the polymer tube could be obtained by stopping the illumination. The diameter of the tube is 4 mm, the wall thickness is about 0.4 mm, and the tensile strength is 0.50 MPA. The outer surface has a rough surface structure, while the inner surface smoothing is favorable to laser processing. This method is simple and rapid and can be produced in batches, and different sizes of artificial blood vessels can be obtained by adjusting different parameters. In this paper, the method of spontaneous and laser processing is used for the first time to realize the bionic structuralization of the inner and outer walls of blood vessels. After swelling and drying, the outer wall of the polymer tube forms an axially balanced "groove" fold pattern, the characteristic size of which can be adjusted in the range of 101-103 渭 m. The inner surface uses femtosecond laser amplifiers to carry out two-dimensional "island" or "grooves" biomimetic micro-nano machining. The small diameter artificial blood vessels prepared by this method not only have bionic internal and external microstructures, but also have good biocompatibility.
【学位授予单位】：吉林大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R318.1;R318.51

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