氨基酸类生物弹性体的制备与性能

发布时间：2018-05-28 16:30

本文选题：生物弹性体 + 木糖醇　；参考：《稀有金属材料与工程》2014年S1期

【摘要】：将谷氨酸引入木糖醇类弹性体,以癸二酸、N-Boc谷氨酸和木糖醇为反应单体,采用熔融缩聚法制备了新型氨基酸类弹性体(PXGS)。结果表明,该弹性体的玻璃化转变温度都低于室温,能和人体组织、器官相匹配;其抗拉伸强度0.17~1.79 MPa、拉伸断裂伸长率226%~972%;材料在pH=7.4的PBS溶液中降解,降解速度可通过改变单体配比调节。此外,弹性体吸水率不大,在水环境中具有较好的稳定性且亲水性能良好。所制备的PXGS制备过程较简便,产物纯净,后处理简单,有望在医学领域用作引导组织修复的膜材料、组织工程支架、药物缓释载体等领域得到应用。
[Abstract]:Glutamic acid was introduced into xylitol elastomer. A new amino acid elastomer, PXGSN, was prepared by melt Polycondensation with N-Boc glutamate and xylitol as reaction monomers. The results show that the glass transition temperature of the elastomer is lower than that of room temperature and can match human tissues and organs. The tensile strength of the elastomer is 0.17 ~ 1.79 MPa, the elongation at tensile break is 226 and 972. The material is degraded in the PBS solution of pH=7.4. The degradation rate can be adjusted by changing the monomer ratio. In addition, the elastomer has little water absorption, good stability and good hydrophilicity in water environment. The prepared PXGS has the advantages of simple preparation, pure product and simple post-treatment. It is expected to be used as membrane material for tissue repair, scaffold for tissue engineering, drug delivery carrier and so on in the field of medicine.
【作者单位】：江南大学;
【基金】：国家自然科学基金(51003042)
【分类号】：TQ334;R318.08

【共引文献】