组织工程学在泌尿外科应用中的研究与进展

发布时间：2018-05-30 07:26

本文选题：泌尿外科手术 + 细胞　；参考：《中国组织工程研究》2017年08期

【摘要】：背景:组织工程学的兴起为泌尿系组织器官缺损的修复提供了新的研究方向,泌尿组织工程学显示出了良好的发展前景。目的:综述近年来国内外对泌尿组织工程学的研究进展。方法:计算机检索相关期刊论文(CNKI)和PubMed数据库2000年1月至2016年1月的相关文章,中文检索词为"组织工程,泌尿外科,种子细胞,支架材料,血管化";英文检索词为"tissue engineering,urology,scaffold,vascularization",选择与泌尿组织工程学概述、支架材料和血管化等方面相关的文章,并进行总结、整理和论述。结果与结论:(1)种子细胞的选择与获取、支架材料的性能、体外组织的构建及血管化程度均对组织工程成功修复泌尿系损伤产生重要影响;(2)适宜的种子细胞是泌尿组织工程研究的基础,不同的种子细胞生物学特性各异,各具优缺点,所以应用时应充分衡量利弊,合理选择;(3)具有良好三维结构的支架材料对于细胞生长增殖、组织长入和血管化等方面均有积极的促进作用;(4)组织工程材料较传统修补材料更具优势,但是目前仅初步应用于临床,尚未形成规模,许多问题尚待解决,例如生产的组织有别于自身组织,功能不完善;生物支架可能出现排异反应,导致再生失败等。
[Abstract]:Background: the rise of tissue engineering provides a new research direction for the repair of urinary tissue and organ defects. Objective: to review the research progress of urinary tissue engineering at home and abroad in recent years. Methods: a computer-based search was conducted for related articles from January 2000 to January 2016 in CNKI and PubMed databases. The key words in Chinese were "tissue engineering, urology, seed cells and scaffold materials". "vascularization"; the English key word is "tissue engineering urology scaffold vascularization". The articles related to urinary tissue engineering, scaffold materials and vascularization are selected, summarized, sorted out and discussed. Results and conclusion: selection and acquisition of seed cells, properties of scaffolds, The construction of tissue in vitro and the degree of vascularization have an important influence on the successful repair of urinary system injury by tissue engineering. The suitable seed cells are the basis of urological tissue engineering research. The biological characteristics of different seed cells are different and have their own advantages and disadvantages. Therefore, the advantages and disadvantages should be fully measured when applied, and a reasonable choice should be made of the scaffold material with a good three-dimensional structure for cell growth and proliferation. Tissue engineering materials have more advantages than traditional repair materials, but at present they are only applied in clinical practice, but have not yet formed scale, and many problems need to be solved. For example, the production tissue is different from its own tissue, the function is not perfect; the biological scaffold may have rejection reaction, resulting in the failure of regeneration, etc.
【作者单位】：济宁医学院;济宁医学院附属医院;
【基金】：国家自然科学基金(81500517,81402119) 山东省自然科学基金(ZR2014HL071,ZR2013CM031,ZR2014HP055) 济宁医学院附属医院博士基金(2016-BS-010)~~
【分类号】：R318.08;R699

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