心脏射血导致重力变化信号的人体实验研究

发布时间：2018-05-31 21:20

本文选题：心冲击信号 + 心脏功能　；参考：《清华大学》2012年硕士论文

【摘要】：心脏疾病的预防、诊断、治疗及预后的关键是准确地获取心脏功能信息。目前临床常规的心脏功能检测技术如心电图、超声心动图及冠脉造影等已经成熟，广泛应用。但是这些检测技术仍有很多的缺点，如灵敏度不高、操作复杂、费用高、特异性及有创等。本研究探索检测心功能的新技术，利用清华大学医疗新技术实验室基于心脏射血重力信号即心冲击的心脏功能检测技术而研发的重力心动信号检测系统，对常见的心脏病病人进行了初步的临床医学试验，并对检测结果进行分析和处理。本文首先介绍了心冲击图的产生原理及国内外研究进展，心冲击信号的特征等。基于心冲击信号的理论基础，介绍了清华大学医疗新技术实验室研发的重力心动图仪的硬件系统和软件的采集分析功能。硬件部分包括重力信号传感器、心电导联、心音探头、脉搏探头和硬件电路。将心电、心音、和脉搏信号与心冲击图同步采集，以作为研究心脏病人BCG信号特征的时间及检测时心脏信息的参考。为了能全面掌握心脏病人的信息，本文对心脏的生理功能和常见心脏病的生理病理特征做了简单介绍。本文最主要的工作是利用重力心动图仪对常见心脏病人进行了初步医学实验，并对检测结果进行了处理和分析。共80位心脏病人接受了重力心动图仪的检测，其中包括冠心病不稳定性心绞痛病人30例，冠心病心肌缺血病人13例，急性冠脉综合症病人7例，急性心肌梗死病人1例，高血压病人7例，高血压心脏病2例，风湿性心脏病2例，主动脉瓣狭窄病人1例，心律失常病人8例，其他9例等。本文综合病人的心电图、动态心电图、超声心动图等临床检查结果，利用与心冲击信号同步采集的心电、心音、脉搏等信息做为心动周期的参考，总结了常见心脏病心冲击信号的特征，并对H/J值与左房增大的关系、I/K值与高血压的关系进行了研究和分析。结果表明，利用该重力信号检测系统能稳定可靠地获取心冲击信号，并且能够从心冲击信号的分析中获得某些常见心脏病的信号特征。
[Abstract]:The key to prevention, diagnosis, treatment and prognosis of heart disease is to obtain accurate cardiac function information. At present, clinical routine cardiac function testing techniques such as electrocardiogram, echocardiography and coronary angiography have been mature and widely used. However, these detection techniques still have many disadvantages, such as low sensitivity, complex operation, high cost, specificity and invasiveness. In this study, a new technique for detecting cardiac function was explored, and a gravity cardiac signal detection system based on cardiac ejection gravity signal was developed by Tsinghua University Medical New Technology Laboratory. A preliminary clinical medical trial was carried out on common heart disease patients, and the results were analyzed and treated. In this paper, we first introduce the principle of cardiogram, the research progress at home and abroad, and the characteristics of cardiac shock signal. Based on the theoretical basis of cardiac impact signal, this paper introduces the hardware system and software acquisition and analysis function of gravity cardiogram developed by Tsinghua University Medical New Technology Laboratory. The hardware part includes gravity signal sensor, ECG lead, heart sound probe, pulse probe and hardware circuit. Electrocardiogram (ECG), heart sound (ECG) and pulse signal were collected synchronously with percussive cardiogram (CPG), which could be used as a reference for studying the characteristics of BCG signal in cardiac patients and detecting cardiac information. In order to master the information of heart patients, this paper briefly introduces the physiological function of heart and the physiological and pathological characteristics of common heart diseases. The main work of this paper is to use the gravity cardiogram to carry on the preliminary medical experiment to the common heart patient, and has carried on the processing and the analysis to the test result. A total of 80 patients were examined by gravity cardiogram, including 30 patients with unstable angina pectoris, 13 patients with myocardial ischemia, 7 patients with acute coronary syndrome and 1 patient with acute myocardial infarction. There were 7 cases of hypertension, 2 cases of hypertensive heart disease, 2 cases of rheumatic heart disease, 1 case of aortic stenosis, 8 cases of arrhythmia and 9 cases of others. In this paper, the clinical results of ECG, ambulatory electrocardiogram, echocardiography and so on were synthesised. The information of ECG, heart sound, pulse and so on, which were collected synchronously with the pulse signal, was used as the reference for the cardiac cycle. The characteristics of heart shock signal in common heart disease were summarized, and the relationship between H / J value and left atrial enlargement was studied and analyzed. The results show that the gravity signal detection system can obtain the heart impact signal stably and reliably, and can obtain the signal characteristics of some common heart disease from the analysis of the heart impact signal.
【学位授予单位】：清华大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R318.0

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