水牛角材料的力学性能与生物学评价

发布时间：2018-06-01 17:45

本文选题：水牛角材料 + 力学性能　；参考：《生物医学工程学杂志》2014年06期

【摘要】：本文对水牛角角蛋白材料的力学性能与生物学评价进行了实验研究。通过单轴拉伸和微米压痕测试方法,探讨取样位置对水牛角材料力学性能的影响,通过元素分析,研究水牛角材料不同部位的元素含量的变化,并采用扫描电子显微镜观察水牛角材料拉伸断裂面的微观结构。此外,通过溶血实验、红细胞形态观察、血液血小板和红细胞计数以及小鼠植入实验,对水牛角材料进行了初步的生物学评价。研究结果表明:水牛角材料具有良好的力学性能,沿着水牛角的生长方向,其各项力学特性值逐渐增大,这与水牛角不同部位的C、N、S含量及其微观结构有密切关系;此外,水牛角材料无毒性,不引起溶血反应,对红细胞具有良好的亲和性以及组织相容性,但水牛角材料可引起血液血小板的黏附、聚集,且并没有继续诱导引发大量血小板聚集而导致血液凝固,具有良好的血液相容性。
[Abstract]:In this paper, the mechanical properties and biological evaluation of buffalo keratin were studied. The influence of sampling position on the mechanical properties of water ox horn material was investigated by uniaxial tension and micron indentation test. Through elemental analysis, the change of element content in different parts of water ox horn material was studied, and scanning electron microscope was used. The microscopic structure of the tensile fracture surface of the water ox horn material was observed. In addition, the preliminary biological evaluation of the water ox horn material was carried out by hemolysis experiment, the observation of red cell morphology, blood platelet and red blood cell count and the experiment of mouse implantation. The results showed that the water ox horn material has good mechanical properties and along the growth side of the water ox horn. In addition, it is closely related to the C, N, S content and its microstructure in different parts of the horns of the water cattle. In addition, the water ox horn material is nontoxic, does not cause hemolytic reaction, and has good affinity and histocompatibility to red blood cells, but buffalo corner material can cause blood platelet adhesion, aggregation, and not Continuous induced platelet aggregation results in blood clotting and good blood compatibility.
【作者单位】：暨南大学生物医学工程系;暨南大学生物工程学系;暨南大学附属第一医院;深圳市医疗器械检测中心;
【基金】：国家自然科学基金资助项目(20976068/B060805) 广东省科技厅科技计划项目
【分类号】：R318.08

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