兼具成骨和抗感染性能的医用金属材料研究进展

发布时间：2018-06-05 11:38

本文选题：医用金属材料 + 表面改性　；参考：《金属学报》2017年10期

【摘要】：材料的成骨性能(即材料表面或周围促进新骨生成的性能)一直以来是大部分骨科植入性医疗器械的首要临床要求。近年来,材料的抗感染或者抗菌性能(尤其是不依赖抗生素的抗感染或者抗菌性能)逐渐成为骨科植入物的另一重要临床要求。因此,开发同时具有成骨和抗感染性能的生物材料对于骨科临床具有重要意义。医用金属材料在骨科植入物中占有重要地位,但兼具这2种性能的金属材料在以往的临床实践或基础研究中都极为少见,最近才得以广泛研究。本文综述了同时具有成骨和抗感染性能的新型医用金属材料的研究进展,介绍相关金属材料以及金属材料表面改性的研究成果,并对材料兼具成骨和抗感染的机理进行分析讨论,提出此类新型医用金属材料的研究展望。
[Abstract]:The osteogenic properties of materials (i.e. the ability of promoting new bone formation on or around the surface of materials) have been the primary clinical requirements of most orthopedic implants. In recent years, the anti-infective or antibacterial properties of the materials (especially those independent of antibiotics) have gradually become another important clinical requirement of orthopedic implants. Therefore, it is important for orthopedic clinic to develop biomaterials with both osteogenic and anti-infection properties. Medical metal materials play an important role in orthopedic implants, but metal materials with both properties are rare in the past clinical practice or basic research, and have been widely studied recently. In this paper, the research progress of new medical metal materials with both osteogenic and anti-infective properties is reviewed, and the research results of related metal materials and surface modification of metal materials are introduced. The mechanism of both osteogenesis and anti-infection of the materials was analyzed and discussed, and the research prospect of this kind of new medical metal materials was put forward.
【作者单位】：苏州大学骨科研究所;湖北大学材料科学与工程学院;深圳大学医学部基础医学院;苏州大学国际骨转化医学联合研究中心;
【基金】：国家自然科学基金项目Nos.81501858、51672184和81622032 江苏省“双创团队”和“双创人才”项目No.BY2014159-07 江苏省高校优势学科建设工程项目(PAPD)~~
【分类号】：R318.08;TG14

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